[1-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalen-2-yl]methyl acetate | 883221-14-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [1-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalen-2-yl]methyl acetate
• 英文别名: [1-(3,4,5-Trimethoxyphenyl)-3,4-dihydronaphthalen-2-yl]methyl acetate
• CAS: 883221-14-5
• 化学式: C₂₂H₂₄O₅
• 分子量: 368.43
• InChiKey: XAAPEOFCOZOHMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [1-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalen-2-yl]methyl acetate 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以78%的产率得到[1-(3,4,5-trimethoxyphenyl)naphthalen-2-yl]methyl acetate
  参考文献：
  名称：

  Methodology for the synthesis of 1,2-disubstituted arylnaphthalenes from α-tetralones

  摘要：

  alpha-Tetralones were initially converted into 1-bromo-dihydronaphthalene-2-carbaldehydes and 1-bromo-naphthalene-2carbaldehydes. These precursors were then subjected to Suzuki coupling reactions to afford 1,2-disubstituted aryldihydronaphthalenes and 1,2-disubstituted arylnaphthalenes, respectively. The former products were oxidized with DDQ to give 1,2-disubstituted arylnaphthalenes. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.01.013
• 作为产物：
  描述：

  2-萘甲醛,1-溴-3,4-二氢- 在 四(三苯基膦)钯 吡啶 、 sodium tetrahydroborate 、 sodium carbonate 作用下， 以 乙二醇二甲醚 、 乙醇 、 水 为溶剂， 反应 64.0h， 生成 [1-(3,4,5-trimethoxyphenyl)-3,4-dihydronaphthalen-2-yl]methyl acetate
  参考文献：
  名称：

  Methodology for the synthesis of 1,2-disubstituted arylnaphthalenes from α-tetralones

  摘要：

  alpha-Tetralones were initially converted into 1-bromo-dihydronaphthalene-2-carbaldehydes and 1-bromo-naphthalene-2carbaldehydes. These precursors were then subjected to Suzuki coupling reactions to afford 1,2-disubstituted aryldihydronaphthalenes and 1,2-disubstituted arylnaphthalenes, respectively. The former products were oxidized with DDQ to give 1,2-disubstituted arylnaphthalenes. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.01.013

文献信息

• Methodology for the synthesis of 1,2-disubstituted arylnaphthalenes from α-tetralones
  作者：Simon S. Moleele、Joseph P. Michael、Charles B. de Koning

  DOI：10.1016/j.tet.2006.01.013

  日期：2006.3

  alpha-Tetralones were initially converted into 1-bromo-dihydronaphthalene-2-carbaldehydes and 1-bromo-naphthalene-2carbaldehydes. These precursors were then subjected to Suzuki coupling reactions to afford 1,2-disubstituted aryldihydronaphthalenes and 1,2-disubstituted arylnaphthalenes, respectively. The former products were oxidized with DDQ to give 1,2-disubstituted arylnaphthalenes. (c) 2006 Elsevier Ltd. All rights reserved.