hygroline | 152517-83-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: hygroline
• 英文别名: (+/-)-Pseudohygrolin；(+/-)-Hygrolin；1-(1-methyl-pyrrolidin-2-yl)-propan-2-ol；1-(1-methylpyrrolidin-2-yl)propan-2-ol
• CAS: 152517-83-4
• 化学式: C₈H₁₇NO
• 分子量: 143.229
• InChiKey: CWMYODFAUAJKIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  碘甲烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 作用下， 生成 hygroline
  参考文献：
  名称：

  Hess, Chemische Berichte, 1913, vol. 46, p. 3123

  摘要：

  DOI：

文献信息

• Pre-analysis treatment method for sample containing plurality of components with greatly different concentrations
  申请人：AiSTI SCIENCE CO., Ltd.

  公开号：US10656126B2

  公开（公告）日：2020-05-19

  A pre-analysis treatment method includes: a first retaining step of supplying, to a solid phase, each predetermined amount of the sample and a first solvent, and allowing a component at low concentration to be retained in the solid phase; a first washing step of supplying the first solvent to the solid phase and removing a component at high concentration from the solid phase; a second retaining step of supplying the sample in a smaller amount than the predetermined amount supplied in the first retaining step, and a second solvent to the solid phase, and allowing the component at high concentration to be retained in the solid phase; and an elution step of simultaneously extruding the components retained in the solid phase with an extrusion solvent.

  一种分析前处理方法包括第一保留步骤：向固相提供各预定量的样品和第一溶剂，并允许低浓度成分保留在固相中； 第一洗涤步骤：向固相提供第一溶剂，并从固相中去除高浓度成分；第二保留步骤：向固相中提供小于第一保留步骤中预定量的样品和第二溶剂，并允许高浓度组分保留在固相中；以及洗脱步骤：同时用挤出溶剂挤出保留在固相中的组分。
• FUSED RING COMPOUNDS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3735299A2

  公开（公告）日：2020-11-11
• PHARMACEUTICAL COMPOSITIONS COMPRISING MONTELUKAST
  申请人：Kappala Ramesh

  公开号：US20090124657A1

  公开（公告）日：2009-05-14

  Pharmaceutical compositions comprising montelukast or pharmaceutically acceptable salts, solvates, polymorphs, enantiomers or mixtures thereof.
• PRE-ANALYSIS TREATMENT METHOD FOR SAMPLE CONTAINING PLURALITY OF COMPONENTS WITH GREATLY DIFFERENT CONCENTRATIONS
  申请人：AiSTI SCIENCE CO., Ltd.

  公开号：US20180209945A1

  公开（公告）日：2018-07-26

  A pre-analysis treatment method includes: a first retaining step of supplying, to a solid phase, each predetermined amount of the sample and a first solvent, and allowing a component at low concentration to be retained in the solid phase; a first washing step of supplying the first solvent to the solid phase and removing a component at high concentration from the solid phase; a second retaining step of supplying the sample in a smaller amount than the predetermined amount supplied in the first retaining step, and a second solvent to the solid phase, and allowing the component at high concentration to be retained in the solid phase; and an elution step of simultaneously extruding the components retained in the solid phase with an extrusion solvent.
• US4614653A
  申请人：——

  公开号：US4614653A

  公开（公告）日：1986-09-30