1,4,8,11-tetraazacyclotetradecane-3,9-dione | 188686-55-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: 1,4,8,11-tetraazacyclotetradecane-3,9-dione
• 英文别名: 1,4,8,11-Tetraazacyclotetradecane-2,10-dione；1,4,8,11-tetrazacyclotetradecane-2,10-dione
• CAS: 188686-55-7
• 化学式: C₁₀H₂₀N₄O₂
• 分子量: 228.294
• InChiKey: DLVUYESUZNSZGG-UHFFFAOYSA-N

物化性质

• 沸点：
  552.1±50.0 °C(Predicted)
• 密度：
  1.012±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  82.3
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N,N'-二(氯乙酰基)-1,3-丙烷二胺 在 钯 甲酸 、 potassium carbonate 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 44.0h， 生成 1,4,8,11-tetraazacyclotetradecane-3,9-dione
  参考文献：
  名称：

  Synthesis, characterization, and Cu(II) solution chemistry of dioxotetraazamacrocycles

  摘要：

  The synthesis and characterization of four new dioxotetraazamacrocycles: 1,4,8,11-tetraazacyclotetradecane-3,9-dione; 1,4,7,10-tetraazacyclotridecane-2,9-dione 1,4,7,10-tetraazacyclotridecane-3,8-dione; and 1,4,7,10-tetraazacyclododecane-2,9-dione are described. Two related, previously prepared macrocycles, are included in this study: 1,4,8,11-tetraazacyclotetradecane-5,7-dione and 1,4,7,10-tetraazacyclotridecane-11,13-dione. The protonation constants, stability constants with Cu2+ ions, as well as electronic spectra of the di-deprotonated copper(II) complexes are also reported. These results are discussed in terms of the suitability of this new class of Cu-62, Cu-64, Cu-67 complexes in PET imaging or radiotherapeutic applications. The synthetic schemes outlined provide a study of the relative Cu2+ behavior with a family of positional isomers of unsubstituted dioxotetraazamacrocycles.

  DOI：

  10.1139/cjc-77-5-6-614

文献信息

• Anticancer therapy
  申请人：STC.UNM

  公开号：US10172967B2

  公开（公告）日：2019-01-08

  A subject afflicted with a cancer or precancerous condition is treated by administering an agent that increases expression of somatostatin receptors, and a cytotoxic recognition ligand. In an alternative embodiment, somatostatin analogs, which are radiolabeled are used to treat cancer or precancerous conditions.

  治疗癌症或癌前病变的方法是给患者服用一种能增加体生长抑素受体表达的药物和一种细胞毒性识别配体。在另一个实施方案中，使用放射性标记的体生长抑素类似物来治疗癌症或癌前病变。
• Method of diagnosing and/or monitoring therapy of atherosclerosis
  申请人：STC.UNM

  公开号：US10744214B2

  公开（公告）日：2020-08-18

  The present invention is directed to novel non-invasive diagnostic took to dispose numerous disease states and/or conditions. The presets invention, represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. The methods described herein are able to diagnose, treat and/or monitor the therapy of numerous diseases and conditions including atherosclerosis, atherothrombosis, cerebral vascular disease, cerebral ischemia, cerebral infarct and meningitis as well as pneumonitis, pericarditis, multiple sclerosis, lupus erythematosus and pancreatitis, among others.

  本发明涉及新型非侵入性诊断方法，用于诊断多种疾病状态和/或病症。目前，这些疾病的诊断主要依赖于组织活检，而本发明是这一领域的明显进步。新型成像探针能够检测受感染的细胞和组织。本文所述的方法能够诊断、治疗和/或监测多种疾病和病症的治疗，包括动脉粥样硬化、动脉粥样硬化性血栓形成、脑血管疾病、脑缺血、脑梗塞和脑膜炎以及肺炎、心包炎、多发性硬化、红斑狼疮和胰腺炎等。
• Non-invasive diagnostic agents of cancer and methods of diagnosing cancer, especially leukemia and lymphoma
  申请人：Norenberg P Jeffrey

  公开号：US20070048216A1

  公开（公告）日：2007-03-01

  The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
• NON-INVASIVE DIAGNOSTIC AGENTS AND METHODS OF DIAGNOSING INFECTIOUS DISEASE
  申请人：Norenberg Jeffrey P.

  公开号：US20110117014A1

  公开（公告）日：2011-05-19

  The present invention is directed to novel non-invasive diagnostic tools to diagnose numerous infectious disease states or conditions. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. This represents a quanturn step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to therapeutic treatments and other interventions or therapies used in the treatment of these disease states or conditions. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. Pharmaceutical compositions are also described.
• Version of FDG Detectable by Single-Photon Emission Computed Tomography
  申请人：Moore Dennis A.

  公开号：US20110177004A1

  公开（公告）日：2011-07-21

  A compound comprising a metal chelate linked to a hexose carrier for use as a metallopharmaceutical diagnostic or therapeutic agent is provided. The compound is suitable for imaging by single-photon emission computed tomography, computer assisted tomography, magnetic resonance spectroscopy, magnetic resonance imaging, positron emission tomography, fluorescence imaging or x-ray.