Fmoc-Arg-OH

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-Arg-OH
• 英文别名: 5-(diaminomethylideneazaniumyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoate
• 化学式: C₂₁H₂₄N₄O₄
• mdl: MFCD30479410
• 分子量: 396.446
• InChiKey: DVBUCBXGDWWXNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  哌啶 、 Fmoc-Arg-OH 在 吡啶 、 1-羟基苯并三唑 作用下， 生成 2-(7-amino-3-iminio-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)benzoate
  参考文献：
  名称：

  CHROMOGENIC AND FLUOROGENIC COMPOUNDS AND THEIR USE FOR BIOLOGICAL DETECTION

  摘要：

  The disclosure provides chromogenic and fluorogenic compounds comprising amino acid or peptide appendages that are capable of detecting an activity in a bioassay. Also provided herein are methods for detecting a biological activity in a sample with the subject chromogenic and fluorogenic compounds. In one embodiment, provided herein is a method for detecting endotoxin in a sample. Further provided herein are kits including the subject chromogenic and fluorogenic compounds for detecting a biological activity in a sample.

  公开号：

  US20240272146A1
• 作为产物：
  描述：

  氯甲酸-9-芴基甲酯 、 L-精氨酸 生成 Fmoc-Arg-OH
  参考文献：
  名称：

  LaborPraxis, 18 (1994) N 8, S 38

  摘要：

  DOI：

文献信息

• [EN] LACTOFERRIN FRAGMENT FOR THE USE AS ANTIBACTERIAL AND ANTIVIRAL AGENT<br/>[FR] FRAGMENT DE LACTOFERRINE DESTINÉ À ÊTRE UTILISÉ EN TANT QU'AGENT ANTIBACTÉRIEN ET ANTIVIRAL
  申请人：FARMAGENS HEALTH CARE SRL

  公开号：WO2017025846A1

  公开（公告）日：2017-02-16

  New peptide fragments of bovine lactoferrin having antimicrobial and antiviral activity, and derivatives thereof, used as active principle in antimicrobial and antiviral agents and compositions.

  牛乳铁蛋白的新型肽片段具有抗微生物和抗病毒活性，以及其衍生物，用作抗微生物和抗病毒剂和组合物中的活性成分。
• 피부 질환 개선용 조성물
  申请人：UniqueMedicare Co., Ltd. 주식회사 유니크메디케어(120110543369) Corp. No ▼ 110111-4527317BRN ▼119-86-38328

  公开号：KR20190102610A

  公开（公告）日：2019-09-04

  본 발명은 하기 화학식 1로 표시되는 화합물을 포함하는 피부 질환 개선용 조성물에 관한 것이다. [화학식 1] 본 발명의 화합물은 UV 에 의한 피부 세포 손상을 회복시키고, 피부 상재균에 대한 항균 활성을 가지며, tyrosinase 활성을 억제하여 피부 질환을 개선하는 특징이 있다. 또한 본 발명의 화합물은 피부개선용 기능성 화장품의 원료로 사용이 가능하다.

  本发明涉及一种用于改善皮肤疾病的组合物，其包含以下化合物，化学式表示为1。该化合物具有恢复受紫外线损伤的皮肤细胞、抗菌活性对皮肤表面菌株以及抑制酪氨酸酶活性以改善皮肤疾病的特点。此外，该化合物可用作皮肤改善型功能化妆品的原料。
• [EN] METHOD AND COMPOSITIONS FOR REMOVING ACID-LABILE PROTECTING GROUPS<br/>[FR] PROCÉDÉ ET COMPOSITIONS POUR L'ÉLIMINATION DE GROUPES PROTECTEURS LABILES EN MILIEU ACIDE
  申请人：STETSENKO DMITRY

  公开号：WO2014033466A1

  公开（公告）日：2014-03-06

  A method for removing acid-labile protecting groups from a protected compound that has one or more acid-labile protecting groups, said method comprising: a. dissolving or dispersing the protected compound, or immersing a solid support to which the protected compound is attached, in a mixture comprising i) a fluoro alcohol, ii) an acid and, optionally, iii) an organic solvent and/or a scavenger; and b. maintaining the resulting solution or dispersion, or keeping the solid support immersed, for a period of time sufficient to ensure the removal of one or more acid-labile protecting groups from said protected compound, thereby producing a deprotected or partially protected compound. The protected compound may be, for example, a peptide. There is also provided a composition for use in such a method, said composition comprising i) a fluoro alcohol; ii) an acid and, optionally, iii) an organic solvent and/or a scavenger.