1,1a(2)-(1-Propyl-1,2-ethenediyl)bis[benzene] | 4720-94-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1,1a(2)-(1-Propyl-1,2-ethenediyl)bis[benzene]
• 英文别名: 1-phenylpent-1-en-2-ylbenzene
• CAS: 4720-94-9
• 化学式: C₁₇H₁₈
• 分子量: 222.33
• InChiKey: UZGXEGZDMGIPAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-氰基乙酰基色酮 、 1,1a(2)-(1-Propyl-1,2-ethenediyl)bis[benzene] 在 manganese(III) triacetate dihydrate 作用下， 以 溶剂黄146 为溶剂， 生成 2-(1-benzofuran-2-yl)-5-propyl-4,5-diphenyl-4,5-dihydrofuran-3-carbonitrile
  参考文献：
  名称：

  Synthesis and biological activity studies of furan derivatives

  摘要：

  The organic compounds, 4-Ethyl-2,5,5-triphenyl-4,5-dihydrofuran-3-carbonitrile; 2,4,5-Triphenyl-5-propyl-4,5-dihydrofuran-3-carbonitrile; 4-Ethyl-5,5-diphenyl-2-thien-2-yl-4,5-dihydrofuran-3-carbonitrile; 2-(1-Benzofuran-2-yl-)-5-propyl-4,5-diphenyl-4,5-dihydrofuran-3-carbonitrile; 4-Ethyl-5,5-diphenyl-4,5-dihydro-2,2'-bifuran-3-carbonitrile, were synthesized and purified through column chromatography and preparative TLC. All compounds were characterized by IR, (1)H, (13)C NMR, MS, and microanalysis. The in vitro antibacterial and antifungal activities of these compounds were investigated against some bacteria and fungi. The antibacterial and antifungal activities were measured by using the disc-diffusion method against gram-positive bacteria, i.e., Staphylococcus aureus ATCC 25923, Staphylococcus enteritidis ATCC1376, Psydomamonas aeruginosa ATCC 29212, Bacillus subtilis RSKK 244, Bacillus megaterium gram-negative bacteria Escherichia coli ATCC 27853, Listeria monocytogenes ATCC 7644, and as fungus Micrococcus Luteus NRRLB was used. All compounds in this study showed activity against test bacteria. Their antibiogram tests showed better results than some known antibiotics.

  DOI：

  10.1007/s00044-009-9206-8

文献信息

• Synthesis and biological activity studies of furan derivatives
  作者：Elif Loğoğlu、Mehmet Yilmaz、Hikmet Katircioğlu、Mehtap Yakut、Sercan Mercan

  DOI：10.1007/s00044-009-9206-8

  日期：2010.6

  The organic compounds, 4-Ethyl-2,5,5-triphenyl-4,5-dihydrofuran-3-carbonitrile; 2,4,5-Triphenyl-5-propyl-4,5-dihydrofuran-3-carbonitrile; 4-Ethyl-5,5-diphenyl-2-thien-2-yl-4,5-dihydrofuran-3-carbonitrile; 2-(1-Benzofuran-2-yl-)-5-propyl-4,5-diphenyl-4,5-dihydrofuran-3-carbonitrile; 4-Ethyl-5,5-diphenyl-4,5-dihydro-2,2'-bifuran-3-carbonitrile, were synthesized and purified through column chromatography and preparative TLC. All compounds were characterized by IR, (1)H, (13)C NMR, MS, and microanalysis. The in vitro antibacterial and antifungal activities of these compounds were investigated against some bacteria and fungi. The antibacterial and antifungal activities were measured by using the disc-diffusion method against gram-positive bacteria, i.e., Staphylococcus aureus ATCC 25923, Staphylococcus enteritidis ATCC1376, Psydomamonas aeruginosa ATCC 29212, Bacillus subtilis RSKK 244, Bacillus megaterium gram-negative bacteria Escherichia coli ATCC 27853, Listeria monocytogenes ATCC 7644, and as fungus Micrococcus Luteus NRRLB was used. All compounds in this study showed activity against test bacteria. Their antibiogram tests showed better results than some known antibiotics.