(+/-)-3-O-Acetyl-8-iso-oestradiol | 4245-41-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (+/-)-3-O-Acetyl-8-iso-oestradiol
• 英文别名: (17-Hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl) acetate
• CAS: 4245-41-4；15068-98-1；23357-04-2；70470-27-8；145164-85-8
• 化学式: C₂₀H₂₆O₃
• 分子量: 314.425
• InChiKey: FHXBMXJMKMWVRG-UHFFFAOYSA-N

物化性质

• 熔点：
  136.5-137.5 °C(Solv: methanol (67-56-1))
• 沸点：
  455.5±45.0 °C(Predicted)
• 密度：
  1.156±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  estradiol 、 1-乙酰-1H-1,2,3-三唑[4,5-b]吡啶 在 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 1.0h， 以98%的产率得到(+/-)-3-O-Acetyl-8-iso-oestradiol
  参考文献：
  名称：

  Selective acylations of aminophenols and hydroxyalkylphenols with 1-acetyl--triazolo[4,5-b]pyridine

  摘要：

  DOI：

  10.1016/s0040-4039(00)85125-4

文献信息

• MANGANESE (III) CATALYZED C--H AMINATIONS
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20190106448A1

  公开（公告）日：2019-04-11

  Reactions that directly install nitrogen into C—H bonds of complex molecules are significant because of their potential to change the chemical and biological properties of a given compound. Selective intramolecular C—H amination reactions that achieve high levels of reactivity, while maintaining excellent site-selectivity and functional-group tolerance is a challenging problem. Herein is reported a manganese perchlorophthalocyanine catalyst [Mn III (ClPc)] for intermolecular benzylic C—H amination of bioactive molecules and natural products that proceeds with unprecedented levels of reactivity and site-selectivity. In the presence of Brønsted or Lewis acid, the [Mn III (ClPc)]-catalyzed C—H amination demonstrates unique tolerance for tertiary amine, pyridine and benzimidazole functionalities. Mechanistic studies indicate that C—H amination proceeds through an electrophilic metallonitrene intermediate via a stepwise pathway where C—H cleavage is the rate-determining step of the reaction. Collectively these mechanistic features contrast previous base-metal catalyzed C—H aminations.

  直接将氮原子安装到复杂分子中的C-H键的反应具有重要意义，因为它们有可能改变给定化合物的化学和生物性质。实现高反应性，同时保持优秀的位点选择性和官能团耐受性的选择性分子内C-H胺化反应是一个具有挑战性的问题。本文报道了一种锰过氯酞菁催化剂[MnIII(ClPc)]，用于分子间苄基C-H胺化反应，该反应在生物活性分子和天然产物中以前所未有的反应性和位点选择性进行。在Brønsted酸或Lewis酸的存在下，[MnIII(ClPc)]催化的C-H胺化展示了对叔胺、吡啶和苯并咪唑官能团的独特耐受性。机理研究表明，C-H胺化通过亲电金属亚硝烯中间体经过分步途径进行，其中C-H裂解是反应的速率决定步骤。总的来说，这些机理特征与之前基于贱金属催化的C-H胺化反应形成了对比。
• Manganese (III) catalyzed C—H aminations
  申请人：The Board of Trustees of the University of Illinois

  公开号：US10611786B2

  公开（公告）日：2020-04-07

  Reactions that directly install nitrogen into C—H bonds of complex molecules are significant because of their potential to change the chemical and biological properties of a given compound. Selective intramolecular C—H amination reactions that achieve high levels of reactivity, while maintaining excellent site-selectivity and functional-group tolerance is a challenging problem. Herein is reported a manganese perchlorophthalocyanine catalyst [MnIII(ClPc)] for intermolecular benzylic C—H amination of bioactive molecules and natural products that proceeds with unprecedented levels of reactivity and site-selectivity. In the presence of Brønsted or Lewis acid, the [MnIII(ClPc)]-catalyzed C—H amination demonstrates unique tolerance for tertiary amine, pyridine and benzimidazole functionalities. Mechanistic studies indicate that C—H amination proceeds through an electrophilic metallonitrene intermediate via a stepwise pathway where C—H cleavage is the rate-determining step of the reaction. Collectively these mechanistic features contrast previous base-metal catalyzed C—H aminations. The catalyst can be a compound of Formula I:

  在复杂分子的 C-H 键上直接安装氮的反应具有重要意义，因为它们有可能改变特定化合物的化学和生物特性。既能实现高水平反应活性，又能保持良好的位点选择性和官能团耐受性的选择性分子内 C-H 氨化反应是一个具有挑战性的问题。本文报告了一种过氯酞菁锰催化剂 [MnIII(ClPc)]，用于生物活性分子和天然产物的分子间苄基 C-H 氨化反应，其反应活性和位点选择性达到了前所未有的水平。在布氏酸或路易斯酸存在的情况下，[MnIII(ClPc)]催化的 C-H amination 对叔胺、吡啶和苯并咪唑官能团具有独特的耐受性。机理研究表明，C-H 氨化反应是通过亲电茂金属烯中间体逐步进行的，其中 C-H 裂解是反应的决定性步骤。这些机理特征与之前的碱金属催化 C-H amination 形成了鲜明对比。催化剂可以是式 I 的化合物：
• Convenient and Selective Acetylations of Phenols, Amines and Alcohols
  作者：Vandana Srivastava、Amita Tandon、Suprabhat Ray

  DOI：10.1080/00397919208021671

  日期：1992.9

  Two convenient methods have been developed for selective acetylation. In method 1, phenols and amines are selectively acetylated in the presence of alcohols by acetic anhydride in a biphasic aqueous NaOH-isopropanol mixture. In method 2, alcoholic group is acetylated in the presence of amino functions using a strong acidic resin.
• Selective acylations of aminophenols and hydroxyalkylphenols with 1-acetyl--triazolo[4,5-b]pyridine
  作者：Mario Paglialunga Paradisi、Giampiero Pagani Zecchini、Ines Torrini

  DOI：10.1016/s0040-4039(00)85125-4

  日期：1986.1