2-methoxy-6-methyl-tetrahydro-pyran | 18653-59-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2-methoxy-6-methyl-tetrahydro-pyran
• 英文别名: 2-Methoxy-6-methyloxan；2-Methoxy-6-methyltetrahydropyran；2-methoxy-6-methyloxane
• CAS: 18653-59-3
• 化学式: C₇H₁₄O₂
• 分子量: 130.187
• InChiKey: FNEUIJOQHOUXIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methoxy-6-methyl-tetrahydro-pyran 、 1-(triisopropylsiloxy)-1-hexyne 在 2,4,6-三甲基吡啶 、 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 以83%的产率得到(Z)-3-butyl-8-methyl-5,6,7,8-tetrahydro-2H-oxocin-2-one
  参考文献：
  名称：

  一种无需高稀释或慢加的高效合成中环和大环内酯的新策略

  摘要：

  我们通过概念上不同的扩环策略开发了一种有效的中环和大环内酯合成方法。The design of an unprecedented ring conjunction mode of oxetene, combined with the appropriate choice of a Lewis acid promoter and an additive, constitutes the key components of the new process. 通过这种新方法，反应不需要高度稀释或缓慢添加。

  DOI：

  10.1021/ja400883q
• 作为产物：
  描述：

  (E)-6-Trimethylsilanyl-hex-5-en-2-ol 在 三氟化硼乙醚 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成 2-methoxy-6-methyl-tetrahydro-pyran
  参考文献：
  名称：

  Floerke, Holger; Schaumann, Ernst, Synthesis, 1996, # 5, p. 647 - 651

  摘要：

  DOI：

文献信息

• Synthesis of medium-sized lactones from siloxy alkynes via ring expansion
  作者：An Wu、Wanxiang Zhao、Jianwei Sun

  DOI：10.1016/j.tet.2020.131163

  日期：2020.12

  topic in organic synthesis due to the disfavored kinetic and thermodynamic features. Herein we detail an efficient intermolecular process using siloxy alkynes as substrates and oxetene ring expansion as the key strategy. With extension to a new silyl-masked alkyne, this reaction now features a broad scope, high efficiency, and mild conditions.

  由于不利的动力学和热力学特征，中环内酯的合成仍然是有机合成中的挑战性课题。在本文中，我们详细介绍了一种有效的分子间过程，该过程使用甲硅烷氧基炔烃作为底物，以氧杂环丁烷环扩环为关键策略。通过扩展到新的甲硅烷基掩盖的炔烃，该反应现在具有广泛的范围，高效和温和的条件。
• [EN] MRNA CAP ANALOGS AND METHODS OF MRNA CAPPING<br/>[FR] ANALOGUES DE COIFFES ARNM ET PROCÉDÉS DE COIFFAGE D'ARNM
  申请人：MODERNATX INC

  公开号：WO2017066793A1

  公开（公告）日：2017-04-20

  The present disclosure relates to cap analogs of formula (I) as defined in claim 1, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.

  本公开涉及公式（I）中定义的帽子类似物，其可以导致高水平的帽子效率和转录以及改善的翻译效率。本公开还涉及用于制备帽子类似物和使用包含此类类似物的mRNA物种的方法，以及包含新型帽子类似物的试剂盒。
• NONAQUEOUS ELECTROLYTE SOLUTION AND ENERGY DEVICE USING SAME
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US20200274199A1

  公开（公告）日：2020-08-27

  The present invention provides an energy device having excellent properties. Also provided is a nonaqueous electrolyte solution containing a compound represented by the following Formula (1), wherein R 11 , R 12 and R 13 each independently represent an organic group having 1 to 3 carbon atoms; and R 11 and R 12 , R 11 and R 13 , or R 12 and R 13 are optionally bound with each other to form a 5-membered ring or a 6-membered ring, with a proviso that a total number of carbon atoms of R 11 , R 12 and R 13 is 7 or less.

  本发明提供了一种具有优异性能的能源装置。同时还提供了一种非水电解质溶液，其中包含由以下式（1）表示的化合物，其中R11、R12和R13各自独立地表示具有1到3个碳原子的有机基团；且R11和R12、R11和R13或R12和R13可以选择地相互结合形成一个5元环或6元环，条件是R11、R12和R13的总碳原子数不超过7。
• Production Process Of Tetrahydropyran Compound And Tetrahydropyran Compound Produced By The Production Process
  申请人：Yamagami Isao

  公开号：US20080139828A1

  公开（公告）日：2008-06-12

  The invention provides a production, process of a tetrahydropyran compound, characterized by allowing 3,4-dihydro-2-alkoxy-2H-pyran compound or tetrahydro-2-alkoxy-2H-pyran compound which can be easily prepared through reaction between acrolein and alkylvinylether, with hydrogen in the presence of a catalyst containing an element of Groups VIII to X under acidic condition. The production process of the invention is useful for production of Grignard reaction solvent or polymer solvent and intermediate of organic compound.

  本发明提供了一种四氢吡喃化合物的生产方法，其特点在于在酸性条件下，在含有VIII至X族元素的催化剂存在下，使3,4-二氢-2-烷氧基-2H-吡喃化合物或可以通过丙烯醛和烷基乙烯醚反应轻松制备的四氢-2-烷氧基-2H-吡喃化合物与氢反应。本发明的生产过程适用于格氏试剂反应溶剂或聚合物溶剂和有机化合物的中间体的生产。
• ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, RESIST FILM USING THE SAME, PATTERN FORMING METHOD, MANUFACTURING METHOD OF ELECTRONIC DEVICE, ELECTRONIC DEVICE AND RESIN
  申请人：FUJIFILM Corporation

  公开号：US20150132688A1

  公开（公告）日：2015-05-14

  There is provided an actinic ray-sensitive or radiation-sensitive resin composition comprising (P) a resin having (a) a repeating unit represented by the specific formula; a resist film formed using the actinic ray-sensitive or radiation-sensitive resin composition; a pattern forming method comprising (i) a step of forming a film by using the actinic ray-sensitive or radiation-sensitive resin composition, (ii) a step of exposing the film, and (iii) a step of developing the exposed film by using a developer to form a pattern; a method for manufacturing an electronic device, comprising the pattern forming method; and an electronic device manufactured by the manufacturing method of an electronic device.

  提供了一种光致射线敏感或辐射敏感的树脂组合物，其中包括（P）具有（a）由特定公式表示的重复单元的树脂；使用该光致射线敏感或辐射敏感的树脂组合物形成的抗蚀膜；包括（i）使用该光致射线敏感或辐射敏感的树脂组合物形成膜的步骤，（ii）曝光膜的步骤，以及（iii）使用显影剂显影曝光的膜以形成图案的图案形成方法；一种制造电子设备的方法，包括图案形成方法；以及通过电子设备的制造方法制造的电子设备。