7-(1,3-Benzodioxol-5-yl)-1-piperidin-1-ylhepta-2,4-dien-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 7-(1,3-Benzodioxol-5-yl)-1-piperidin-1-ylhepta-2,4-dien-1-one
• 英文别名: 7-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylhepta-2,4-dien-1-one
• 化学式: C₁₉H₂₃NO₃
• 分子量: 313.4
• InChiKey: FNECAUUPWFQEGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Aromatische Alkensäurederivate zur Appetithemmung und Stimmungsaufhellung
  申请人：Symrise AG

  公开号：EP2918270A1

  公开（公告）日：2015-09-16

  Vorgeschlagen werden primär aromatische Alkensäurederivate der Formel I, zur Anwendung in einem therapeutischen Verfahren als (a) Mittel zur Reduzierung des Appetits und/oder (b) Mittel zur Vermittlung eines Gefühls von Sättigung und/oder als (c) Mittel zur Reduzierung der Energieaufnahme und/oder als (d) Stimmungsaufheller, sowie die nichttherapeutische Verwendung der aromatischen Alkensäurederivate nach Formel I als (a) Mittel zur Reduzierung des Appetits und/oder (b) Mittel zur Vermittlung eines Gefühls von Sättigung und/oder als (c) Mittel zur Reduzierung der Energieaufnahme und/oder als (c) Stimmungsaufheller.

  提出的主要是式 I 的芳香族烯酸衍生物，在治疗方法中用作(a)降低食欲的制剂和/或(b)赋予饱腹感的制剂和/或(c)降低能量摄入的制剂和/或(d)情绪促进剂、以及根据式 I 的芳香族烯酸衍生物作为(a)降低食欲的制剂和/或(b)赋予饱腹感的制剂和/或作为(c)降低能量摄入的制剂和/或作为(c)情绪促进剂的非治疗用途。
• COMPOSITIONS COMPRISING EXTRACTS OF APLINIA AND OTHER PLANTS FOR IMPROVING JOINT HEALTH AND TREATING ARTHRITIS
  申请人：Unigen, Inc.

  公开号：EP4100034A1

  公开（公告）日：2022-12-14
• AROMATIC ALKENOIC ACID DERIVATIVES
  申请人：Symrise AG

  公开号：US20150259319A1

  公开（公告）日：2015-09-17

  What are proposed are primarily aromatic alkenoic acid derivatives of the formula I for use in a therapeutic method as (a) means for reducing appetite and/or (b) means for causing a feeling of satiation and/or as (c) means for reducing energy intake and/or as (d) mood enhancers, and the non-therapeutic use of the aromatic alkenoic acid derivatives of formula I as (a) means for reducing appetite and/or (b) means for causing a feeling of satiation and/or as (c) means for reducing energy intake and/or as (d) mood enhancers.
• COMBINATION REMEDY
  申请人：SYMRISE AG

  公开号：US20220071933A1

  公开（公告）日：2022-03-10

  The present invention primarily relates to a combination agent for reducing appetite and/or for providing a feeling of satiety and/or for reducing energy intake and/or for reducing body weight. In addition, the present invention relates to a medical use of the combination agent, in particular for the treatment of overweight and obesity and for the prevention of cardiovascular disease, stroke, diabetes, and joint damage and wear of the spine, and to a non-therapeutic use of the combination agent. In particular, the focus of the present invention is on the use of the combination agent to provide a feeling of satiety and/or to reduce energy intake and/or to reduce body weight. Finally, the present invention relates to the use of the combination agent for the preparation of an orally consumable preparation or food ingredient and an orally consumable preparation or food ingredient prepared therefrom.
• [EN] COMPOSITIONS COMPRISING EXTRACTS OF APLINIA AND OTHER PLANTS FOR IMPROVING JOINT HEALTH AND TREATING ARTHRITIS<br/>[FR] COMPOSITIONS COMPRENANT DES EXTRAITS D'APLINIA ET D'AUTRES PLANTES POUR AMÉLIORER LA SANTÉ ARTICULAIRE ET TRAITER L'ARTHRITE
  申请人：UNIGEN INC

  公开号：WO2021159042A1

  公开（公告）日：2021-08-12

  Medicinal plant extracts and their bioactives from Alpinia, Magnolia, Kochia and Piper/Pepper are disclosed herein in combination or alone in regulating homeostasis of chondrocytes, extracellular matrix, articular cartilage, and phenotype of arthritis that lead to enhanced anabolic functions of chondrocytes, increased renewal/rebuilding/regeneration of extracellular matrix and articular cartilage, and improved phenotype of osteoarthritis and rheumatoid arthritis.