2-chloro-N-[4-(dimethylamino)benzyl]-N-{3-phenyl-3-[4-(propan-2-yloxy)phenyl]propyl}acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-N-[4-(dimethylamino)benzyl]-N-{3-phenyl-3-[4-(propan-2-yloxy)phenyl]propyl}acetamide
• 英文别名: 2-chloro-N-[[4-(dimethylamino)phenyl]methyl]-N-[3-phenyl-3-(4-propan-2-yloxyphenyl)propyl]acetamide
• 化学式: C₂₉H₃₅ClN₂O₂
• 分子量: 479.1
• InChiKey: FRYFEHAKTZZMLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Combination comprising pterostilbene for the treatment of cancer
  申请人：FUNDACIÓN UNIVERSIDAD CATÓLICA DE VALENCIA SAN VICENTE MÁRTIR

  公开号：US11179348B2

  公开（公告）日：2021-11-23

  The present invention relates to a combination comprising pterostilbeneor pterostilbene phosphate or a pharmaceutically acceptable salt thereof, a glutathione depleting agent and a cancer chemotherapeutic agent. The invention also relates to the medical use of this combination, in particular for the treatment and/or prevention of cancer.

  本发明涉及一种由紫檀芪或紫檀芪磷酸酯或其药学上可接受的盐、谷胱甘肽消耗剂和癌症化疗剂组成的组合物。本发明还涉及这种组合物的医疗用途，特别是用于治疗和/或预防癌症。
• COMBINATION COMPRISING PTEROSTILBENE FOR THE TREATMENT OF CANCER
  申请人：FUNDACIÓN UNIVERSIDAD CATÓLICA DE VALENCIA SAN VICENTE MÁRTIR

  公开号：US20180214390A1

  公开（公告）日：2018-08-02

  The present invention relates to a combination comprising pterostilbeneor pterostilbene phosphate or a pharmaceutically acceptable salt thereof, a glutathione depleting agent and a cancer chemotherapeutic agent. The invention also relates to the medical use of this combination, in particular for the treatment and/or prevention of cancer.