毒理性
◉ 母乳喂养期间的使用总结:目前没有关于母乳喂养期间使用苯托品的信息。长期使用苯托品可能会减少乳汁产量或乳汁排放,但单次剂量不太可能影响母乳喂养。在长期使用期间,观察乳汁减少的迹象(例如,不饱足,体重增长不良)。
◉ 对哺乳婴儿的影响:截至修订日期,没有找到相关的已发布信息。
◉ 对泌乳和母乳的影响:截至修订日期,没有在哺乳母亲中找到相关的已发布信息。抗胆碱药可以在动物中抑制泌乳,显然是通过抑制生长激素和催产素的分泌。[1][2][3][4][5] 抗胆碱药还可以减少非哺乳女性的血清催乳素水平。[6] 对于已经建立泌乳的母亲,催乳素水平可能不会影响她的哺乳能力。
◉ Summary of Use during Lactation:No information is available on the use of benztropine during breastfeeding. Long-term use of benztropine might reduce milk production or milk letdown, but a single dose is not likely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation (e.g., insatiety, poor weight gain).
◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk:Relevant published information in nursing mothers was not found as of the revision date. Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion.[1][2][3][4][5] Anticholinergic drugs can also reduce serum prolactin in nonnursing women.[6] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
来源:Drugs and Lactation Database (LactMed)