5,5-二乙基-1,3-噻唑烷-2,4-二酮 | 89295-61-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 5,5-二乙基-1,3-噻唑烷-2,4-二酮
• 英文名称: 5,5-diethyl-thiazolidine-2,4-dione
• 英文别名: 5,5-Diaethyl-thiazolidin-2,4-dion；5,5-Diethyl-1,3-thiazolidine-2,4-dione
• CAS: 89295-61-4
• 化学式: C₇H₁₁NO₂S
• 分子量: 173.236
• InChiKey: ICKLQYXMLPQXJG-UHFFFAOYSA-N

物化性质

• 熔点：
  76 °C(Solv: ligroine (8032-32-4))
• 沸点：
  165 °C(Press: 14 Torr)
• 密度：
  1.148±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,5-二乙基-1,3-噻唑烷-2,4-二酮 在 sodium hydroxide 作用下， 生成 2,2-diethyl-5-hydroxy-thiomorpholin-3-one
  参考文献：
  名称：

  Some Derivatives of 2,3-Dihydro-4H-1,4-thiazin-3-one and 1,4-Thiazane

  摘要：

  DOI：

  10.1021/ja01523a066
• 作为产物：
  描述：

  2-溴二乙基乙酸 在 盐酸 作用下， 生成 5,5-二乙基-1,3-噻唑烷-2,4-二酮
  参考文献：
  名称：

  Zur Kenntnis der Eigenschaften的研究者和研究者III：用5斯特隆双子代取代剂2,4-二氧杂噻唑烷mit narkotischen Eigenschaften合成

  摘要：

  DOI：

  10.1002/hlca.193702001186

文献信息

• Substituted pyrrolo[3,4-e]indolizines, imidazo[1,2-a]pyrrolo[3,4-e]pyridines, pyrrolo[3,4-e][1,2,4]triazolo[1,5-a]pyridines and pyrrolo[3,4-e][1,2,4]triazolo[4,3-a]pyridines as positive allosteric modulators of muscarinic acetylcholine receptor M1
  申请人：Vanderbilt University

  公开号：US10221175B2

  公开（公告）日：2019-03-05

  Substituted pyrrolopyridine, imidazopyridine and triazolopyridine compounds having a formula are positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1) and the compounds and their pharmaceutical compositions may be useful in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. Compounds of the invention may be prepared in several steps from 2-halo-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one intermediates.

  具有以下式子的被取代的吡咯并吡啶、咪唑并吡啶和三唑并吡啶化合物 是毒蕈碱乙酰胆碱受体 M1（mAChR M1）的正异构调节剂，这些化合物及其药物组合物可用于治疗与毒蕈碱乙酰胆碱受体功能障碍相关的神经和精神疾病。本发明的化合物可由 2-卤-5,6-二氢-7H-吡咯并[3,4-b]吡啶-7-酮中间体分几步制备。
• Binary compositions as disruptors of orco-mediated odorant sensing
  申请人：VANDERBILT UNIVERSITY

  公开号：US10791739B2

  公开（公告）日：2020-10-06

  In one aspect, the invention relates to binary compositions that disrupt ORco-mediated odorant sensing. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in organisms that express ORco receptors such as airborne insects, e.g., mosquitoes, and ticks. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，本发明涉及破坏 ORco 介导的气味感应的二元组合物。特别是，本发明提供的化合物和组合物可以抑制表达 ORco 受体的生物（如空气传播的昆虫，如蚊子和蜱虫）的感官（如宿主靶向）功能。此外，还提供了使用这些制剂的方法以及包含这些制剂的物品。本摘要旨在作为一种扫描工具，用于特定技术领域的搜索，而非对本发明的限制。
• Doran; Shonle, Journal of Organic Chemistry, 1938, vol. 3, p. 195
  作者：Doran、Shonle

  DOI：——

  日期：——
• DE670684
  申请人：——

  公开号：——

  公开（公告）日：——
• BINARY COMPOSITIONS AS DISRUPTORS OF ORCO-MEDIATED ODORANT SENSING
  申请人：VANDERBILT UNIVERSITY

  公开号：US20180092359A1

  公开（公告）日：2018-04-05

  In one aspect, the invention relates to binary compositions that disrupt ORco-mediated odorant sensing. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in organisms that express ORco receptors such as airborne insects, e.g., mosquitoes, and ticks. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.