2-Isocyanato-1-phenyl-propan | 65535-55-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Isocyanato-1-phenyl-propan
• 英文别名: (2-isocyanato-propyl)-benzene；1-methyl-2-phenyl-ethyl isocyanate；1-Methyl-2-phenyl-aethylisocyanat；(2-Isocyanatopropyl)benzene；2-isocyanatopropylbenzene
• CAS: 65535-55-9
• 化学式: C₁₀H₁₁NO
• mdl: MFCD11612971
• 分子量: 161.203
• InChiKey: JWGFMJHWOOMGMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  29.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Isocyanato-1-phenyl-propan 以76%的产率得到
  参考文献：
  名称：

  ARYA V. P.; DAVID J.; GREWAL R. S., INDIAN J. CHEM. , 1977, B 15, NO 7, 635-640

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 苯 作用下， 生成 2-Isocyanato-1-phenyl-propan
  参考文献：
  名称：

  Jones; Wallis, Journal of the American Chemical Society, 1926, vol. 48, p. 180

  摘要：

  DOI：

文献信息

• [EN] ASSOCIATION OF ANTIMICROBIAL COMPOUNDS WITH SURFACES AND POLYMERS<br/>[FR] ASSOCIATION DE COMPOSES ANTIMICROBIENS A DES SURFACES ET DES POLYMERES
  申请人：BIOSIGNAL LTD

  公开号：WO2005053684A1

  公开（公告）日：2005-06-16

  The invention describes antimicrobial silicone oligomers or polymers comprising a silicone oligomer or polymer associated with at least one compound of formula (I). Also described are methods of associating compounds of formula (I) to surfaces and products thereof.

  该发明描述了含有硅氧烷寡聚物或聚合物的抗菌硅氧烷寡聚物或聚合物，该硅氧烷寡聚物或聚合物与至少一个化合物(I)相关联。还描述了将化合物(I)与表面相关联的方法及其产品。
• Urea and thiourea compounds and compositions for cholesterol management and related uses
  申请人：Dasseux Henri Jean-Louis

  公开号：US20050192347A1

  公开（公告）日：2005-09-01

  The present invention relates to novel urea and thiourea compounds, compositions comprising urea or thiourea compounds, and methods useful for treating and preventing aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, enhancing bile production, enhancing reverse lipid transport, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, modulating C reactive protein, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), a thrombotic disorder, gastrointestinal disease, irritable bowel syndrome (IBS), inflammatory bowel disease (e.g., Crohn's Disease, ulcerative colitis), arthritis (e.g., rheumatoid arthritis, osteoarthritis), autoimmune disease (e.g., systemic lupus erythematosus), scleroderma, ankylosing spondylitis, gout and pseudogout, muscle pain: polymyositis/polymyalgia rheumatica/fibrositis; infection and arthritis, juvenile rheumatoid arthritis, tendonitis, bursitis and other soft tissue rheumatism. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

  本发明涉及新型尿素和硫脲化合物，包含尿素或硫脲化合物的组合物，以及用于治疗和预防衰老、阿尔茨海默病、癌症、心血管疾病、糖尿病肾病、糖尿病视网膜病变、葡萄糖代谢紊乱、血脂异常、脂蛋白异常、增强胆汁产生、增强逆向脂质转运、高血压、阳痿、炎症、胰岛素抵抗、胆汁中脂质的清除、调节C反应蛋白、肥胖、胆汁中氧固醇的清除、胰腺炎、帕金森病、过氧化物酶体增殖激活受体相关的疾病、胆汁中磷脂的清除、肾脏疾病、败血症、代谢综合征疾病（如X综合症）、血栓性疾病、胃肠道疾病、肠易激综合症（IBS）、炎症性肠病（如克罗恩病、溃疡性结肠炎）、关节炎（如类风湿性关节炎、骨关节炎）、自身免疫疾病（如系统性红斑狼疮）、硬皮病、强直性脊柱炎、痛风和假性痛风、肌肉疼痛：多发性肌炎/多发性肌痛症/纤维炎；感染和关节炎、儿童类风湿性关节炎、肌腱炎、滑囊炎和其他软组织风湿病的方法。在某些实施方式中，本发明的化合物、组合物和方法可与其他治疗药物（如降胆固醇和降血糖药物）联合治疗。
• Direct synthesis by cationic polymerization of nitrogen-containing polymers
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0349195A2

  公开（公告）日：1990-01-03

  A method is provided for the direct synthesis of novel polymeric materials functionalized with desirable nitrogen-containing functional groups such as terminal azido, cuano, carbonylamino or thiocarbonylamino groups. Polymerization and functionalization occur in a substantially simultaneous manner. All necessary reactants for the functionalization are present when polymerization is initiated. The nitrogen-containing functional group is provided as a part of a molecule having a release moiety which is preferably resonance stabilized or of tertiary alkyl type and which acts to aid the nitrogen-containing species in functioning as a leaving group.

  本发明提供了一种直接合成新型聚合物材料的方法，该材料具有理想的含氮官能团，如末端叠氮基、氨基、羰基氨基或硫代羰基氨基。聚合和官能化基本上是同时进行的。聚合开始时，官能化所需的所有反应物都已存在。含氮官能团是作为分子的一部分提供的，该分子具有释放基，释放基最好是共振稳定的或叔烷基类型的，其作用是帮助含氮物质作为离去基团发挥作用。
• DENTAL PHOTOPOLYMERIZABLE COMPOSITION FOR 3D PRINTER
  申请人：Shofu Inc.

  公开号：EP3795359A1

  公开（公告）日：2021-03-24

  To provide a dental photopolymerizable composition which can prepare a dental restoration with excellent aesthetic and mechanical properties by optical three-dimensional modeling method (stereolithography). The dental photopolymerizable composition for 3D printer of the present invention comprises: a (a) (meth)acrylate-based polymerizable monomer consisting of a (a1) (meth)acrylate-based polymerizable monomer containing a urethane structure and a (a2) (meth)acrylate-based polymerizable monomer not containing a urethane structure, a (b) cohesive inorganic filler, and a (c) photopolymerization initiator, wherein; a ratio of the (a1) (meth)acrylate-based polymerizable monomer containing a urethane structure and the (a2) (meth)acrylate-based polymerizable monomer not containing a urethane structure in the (a) (meth)acrylate-based polymerizable monomer is 51:80 to 49:20 pts.wt., a ratio of the (a) (meth)acrylate-based polymerizable monomer and the (b) cohesive inorganic filler is 50:91 to 50:9 pts.wt., and the dental photopolymerizable composition for 3D printer contains 0.1 to 5 pts.wt. of the (c) photopolymerization initiator based on 100 pts.wt. of the (a) (meth)acrylate-based polymerizable monomer.

  提供一种牙科光可聚合组合物，该组合物可通过光学三维建模方法（立体光刻）制备出具有优异美学和机械性能的牙科修复体。本发明的 3D 打印机用牙科光聚合组合物包括由含有氨基甲酸酯结构的(a1)(甲基)丙烯酸酯基可聚合单体和不含氨基甲酸酯结构的(a2)(甲基)丙烯酸酯基可聚合单体组成的(a)(甲基)丙烯酸酯基可聚合单体、(b)内聚性无机填料和(c)光聚合引发剂，其中；含有氨基甲酸酯结构的(a1)(甲基)丙烯酸酯基可聚合单体与不含有氨基甲酸酯结构的(a2)(甲基)丙烯酸酯基可聚合单体在(a)(甲基)丙烯酸酯基可聚合单体中的比例为 51：重量比为 51：80 至 49：20。重量比(a)(甲基)丙烯酸酯基可聚合单体与(b)内聚性无机填料的比例为 50:91 至 50:9 个百分点重量比，且用于 3D 打印机的牙科光聚合组合物含有 0.1 至 5 个百分点重量比的(c)光聚合引发剂（基于 100 个百分点重量比的(a)(甲基)丙烯酸酯基可聚合单体）。
• Enic compounds, sulfur-containing polyenic compound, sulfur-containing polythiol compound, high refractive index photocurable composition and cured product thereof
  申请人：——

  公开号：US20030195270A1

  公开（公告）日：2003-10-16

  A composition containing 3,3′-thiobis(propane-1,2-dithiol) and one or more enic compounds which composition is photocurable and can give a cured product having a high refractive index and adequate hardness.

  一种含有 3,3′-硫代双（丙烷-1,2-二硫醇）和一种或多种烯酸化合物的组合物，该组合物具有光固化性，可制成具有高折射率和足够硬度的固化产品。