1-Icosa-5,8,11,14-tetraenylpyrrole-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-Icosa-5,8,11,14-tetraenylpyrrole-2,5-dione
• 化学式: C₂₄H₃₅NO₂
• 分子量: 369.5
• InChiKey: GZNZRHSGGQUYAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  27
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Covalent treatment with thiols of keratin-containing materials
  申请人：Living Proof, Inc.

  公开号：US10993903B2

  公开（公告）日：2021-05-04

  Disclosed are methods of preparing thiol keratin-containing materials, comprising applying a mixture comprising one or more thiol compounds and a catalyst. Methods of preparing cross-linked keratin-containing materials by applying a mixture comprising one or more thiol compounds and an oxidizing agent are also disclosed. Methods of grafting monomeric and polymeric materials on keratin-containing materials to provide a covalent coating on keratin-containing materials are disclosed. A mixture comprising one or more thiol compounds is applied to the keratin-containing material sample. The keratin-containing material sample then comprises a plurality of free thiol groups. A monomer is optionally applied to the keratin-containing material sample to form a plurality of covalent bonds between the free thiol groups and the monomers. The disclosed grafting methods can be carried out with or without catalyst.

  本发明公开了制备含硫醇角蛋白材料的方法，包括使用由一种或多种硫醇化合物和催化剂组成的混合物。还公开了通过使用由一种或多种硫醇化合物和氧化剂组成的混合物制备交联含角蛋白材料的方法。公开了在含角蛋白材料上接枝单体和聚合物材料以在含角蛋白材料上提供共价涂层的方法。将包含一种或多种硫醇化合物的混合物涂抹在含角蛋白材料样品上。这样，含角蛋白材料样品就含有多个游离硫醇基团。可选择将单体应用于含角蛋白材料样品，以在游离硫醇基团和单体之间形成多个共价键。所公开的接枝方法可在使用或不使用催化剂的情况下进行。
• Covalent treatment for keratin-containing materials
  申请人：Living Proof, Inc.

  公开号：US11147759B2

  公开（公告）日：2021-10-19

  Disclosed are methods of grafting monomeric and polymeric materials on keratin-containing material to provide a covalent coating on keratin-containing material. A mixture comprising a reducing agent is applied to the keratin-containing material sample. The keratin-containing material sample then comprises a plurality of free thiol groups. A monomer is applied to the keratin-containing material sample. The free thiol groups react with the monomer to form a plurality of covalent bonds between the free thiol groups and the monomers. The reducing agent and the monomer can be applied separately, semi-simultaneously, or simultaneously. The disclosed methods can be carried out with or without catalyst. The disclosed methods can be carried out with or without an additive.

  本发明公开了在含角蛋白材料上接枝单体和聚合物材料以在含角蛋白材料上提供共价涂层的方法。将含有还原剂的混合物涂抹在含角蛋白材料样品上。然后，含角蛋白材料样品就会包含多个游离硫醇基团。将单体涂抹在含角蛋白材料样品上。游离硫醇基团与单体反应，在游离硫醇基团和单体之间形成多个共价键。还原剂和单体可分别、半同时或同时使用。所公开的方法可在使用或不使用催化剂的情况下进行。在使用或不使用添加剂的情况下，均可实施所公开的方法。
• Cannabinoid receptor agonists and serine hydrolase enzyme inhibitor based anxiolytic therapeutic product
  申请人：Medipure Pharmaceuticals Inc.

  公开号：US11147805B2

  公开（公告）日：2021-10-19

  Provided herein are formulations for treating affective mood disorders. The formulations comprise one or more than one CB receptor agonist and one or more than one serine hydrolase enzyme inhibitor.

  本文提供了用于治疗情感性情绪障碍的制剂。这些制剂包括一种或多种 CB 受体激动剂和一种或多种丝氨酸水解酶抑制剂。
• COVALENT TREATMENT FOR KERATIN-CONTAINING MATERIALS
  申请人：Living Proof, Inc.

  公开号：EP3709964A1

  公开（公告）日：2020-09-23
• COVALENT TREATMENT WITH THIOLS OF KERATIN-CONTAINING MATERIALS
  申请人：Living Proof, Inc.

  公开号：EP3755302A1

  公开（公告）日：2020-12-30