cis-3-[2-Hydroxy-4-(2-methyl-2-nonyl) phenyl] cyclohexanol | 1173724-76-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cis-3-[2-Hydroxy-4-(2-methyl-2-nonyl) phenyl] cyclohexanol
• 英文别名: 2-(3-hydroxycyclohexyl)-5-(2-methylnonan-2-yl)phenol
• CAS: 1173724-76-9
• 化学式: C₂₂H₃₆O₂
• 分子量: 332.5
• InChiKey: HNMJDLVMIUDJNH-UHFFFAOYSA-N

物化性质

• 沸点：
  434.8±45.0 °C(Predicted)
• 密度：
  1.002±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] USE OF THE AMINOALKYLINDOLE JWH-073-M4 AND RELATED COMPOUNDS AS NEUTRAL CB1 RECPTOR ANTAGONISTS FOR THE TREATMENT OF ALCOHOLISM, DRUG ABUSE, OBESITY, AND OBESITY-RELATED DISEASES<br/>[FR] UTILISATION DE L'AMINOALKYLINDOLE JWH-073-M4 ET COMPOSÉS APPARENTÉS COMME ANTAGONISTES NEUTRES DES RÉCEPTEURS AUX CANNABINOÏDES DE TYPE 1 POUR LE TRAITEMENT DE L'ALCOOLISME, DE L'ABUS DE DROGUES, DE L'OBÉSITÉ ET DES MALADIES LIÉES À L'OBÉSITÉ
  申请人：UNIV ARKANSAS

  公开号：WO2013106349A1

  公开（公告）日：2013-07-18

  Novel alkylindoles that bind tightly to cannabinoid receptors and are neutral antagonists for the cannabinoid 1 receptor and agonists for the cannabinoid 2 receptor are provided. These compounds are useful for treating alcoholism and drug abuse and for treating obesity.

  提供了一种新型烷基吲哚化合物，它们与大麻素受体结合紧密，是大麻素1受体的中性拮抗剂和大麻素2受体的激动剂。这些化合物对治疗酗酒和药物滥用以及治疗肥胖症是有用的。
• USE OF THE AMINOALKYLINDOLE JWH-073-M4 AND RELATED COMPOUNDS AS NEUTRAL CB1 RECPTOR ANTAGONISTS FOR THE TREATMENT OF ALCOHOLISM, DRUG ABUSE, OBESITY, AND OBESITY-RELATED DISEASES
  申请人：The Board of Trustees of the University of Arkansas

  公开号：US20150266820A1

  公开（公告）日：2015-09-24

  Novel alkylindoles that bind tightly to cannabinoid receptors and are neutral antagonists for the cannabinoid 1 receptor and agonists for the cannabinoid 2 receptor are provided. These compounds are useful for treating alcoholism and drug abuse and for treating obesity.

  提供了一种新型烷基吲哚化合物，它们能够紧密结合大麻素受体，并且是大麻素1受体的中性拮抗剂和大麻素2受体的激动剂。这些化合物可用于治疗酗酒和药物滥用以及治疗肥胖症。
• Formulations and methods for treating acute cannabinoid overdose
  申请人：Anebulo Pharmaceuticals, Inc.

  公开号：US11141404B1

  公开（公告）日：2021-10-12

  Described herein are uses of the CB1 inhibitors (e.g., antagonists, neutral antagonists, inverse agonists) and various methods of using and administering a CB1 inhibitor to a patient, especially patients showing symptoms of drug overdose or suspected of a drug overdose. Further described herein are uses wherein the CB1 inhibitor is ANEB-001. Further described herein are treatments with a CB1 inhibitor for THC or synthetic cannabinoid overdose.

  本文描述了CB1抑制剂（如拮抗剂、中性拮抗剂、逆激动剂）的用途，以及向患者，特别是出现药物过量症状或疑似药物过量的患者使用和施用CB1抑制剂的各种方法。本文进一步描述了CB1抑制剂为ANEB-001的用途。本文还描述了使用 CB1 抑制剂治疗四氢大麻酚或合成大麻素过量的方法。
• Cannabinoid receptor agonists and serine hydrolase enzyme inhibitor based anxiolytic therapeutic product
  申请人：Medipure Pharmaceuticals Inc.

  公开号：US11147805B2

  公开（公告）日：2021-10-19

  Provided herein are formulations for treating affective mood disorders. The formulations comprise one or more than one CB receptor agonist and one or more than one serine hydrolase enzyme inhibitor.

  本文提供了用于治疗情感性情绪障碍的制剂。这些制剂包括一种或多种 CB 受体激动剂和一种或多种丝氨酸水解酶抑制剂。
• TEST KIT FOR THE QUANTITATIVE DETERMINATION OF NARCOTIC DRUGS
  申请人：Chiron AS

  公开号：EP2875362A1

  公开（公告）日：2015-05-27