1,7-dioxacycloheptacos-17-ene-8,27-dione | 1426264-55-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: 1,7-dioxacycloheptacos-17-ene-8,27-dione
• 英文别名: (17E)-1,7-dioxacycloheptacos-17-ene-8,27-dione
• CAS: 1426264-55-2
• 化学式: C₂₅H₄₄O₄
• 分子量: 408.622
• InChiKey: OTVQKEABASTROT-OWOJBTEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  29
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  pentane-1,5-diyl bis(undec-10-enoate) 在 [W(O)(CHCMe₂Ph(OCMe(CF₃)₂))(1,3-dimesitylimidazol-2-ylidene)(CH₃CN)⁺ tetrakis(3,5-bis(trifluoromethyl)phenylborate)]complex immobilized in ordered mesoporous silica 作用下， 以 氘代苯 为溶剂， 以41%的产率得到
  参考文献：
  名称：

  阳离子亚氨基钨/氧代亚烷基N-杂环卡宾配合物约束下二烯的大环化

  摘要：

  两种钨基催化剂被选择性地固定在有序介孔二氧化硅材料的孔内。X 射线吸收光谱证实了催化剂的结构完整性。与同质类似物相比，固定化钨催化剂表现出显着提高的大环化选择性和Z选择性，从而允许使用高底物浓度。

  DOI：

  10.1002/cctc.202300871

文献信息

• Highly Selective Macrocycle Formations by Metathesis Catalysts Fixated in Nanopores
  作者：Joo-Eun Jee、Jian Liang Cheong、Jaehong Lim、Cheng Chen、Soon Hyeok Hong、Su Seong Lee

  DOI：10.1021/jo302823w

  日期：2013.4.5

  Ruthenium-based metathesis catalysts immobilized on mesocellular siliceous foam (MCF) bearing large nanopores proved highly efficient and selective for macrocyclic ring-closing metathesis (RCM). Kinetic studies revealed that the homogeneous counterpart exhibited far higher activity that accounted for more oligomerization pathways and resulted in less macrocyclization products. Meanwhile, the immobilized catalysts showed lower conversion rates leading to higher yields of macrocyclic products in a given reaction time, with conversion rates and yields dependent upon pore size, catalyst loading density, and linker length. The macrocycle formations via RCM were accelerated by increasing the pore size and decreasing the catalyst loading density while retaining the comparably high yield. The catalysts immobilized on MCF, of which silica surface is rigid and pores are relatively large, showed high conversion rates and yields compared with an analogue immobilized on TentaGel resins, of which backbone becomes flexible upon swelling in the reaction medium. It is noteworthy that the selectivity for the macrocyclic RCM can be significantly improved by tuning the catalyst initiation rates via immobilization onto the support materials in which well-defined three-dimentional network of large nanopores are deployed.