1-[3-(1,2-Dihydroxyethyl)phenyl]ethane-1,2-diol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[3-(1,2-Dihydroxyethyl)phenyl]ethane-1,2-diol
• 化学式: C₁₀H₁₄O₄
• 分子量: 198.219
• InChiKey: IAKQTHANRVTNHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  甲醇 、 1-[3-(1,2-Dihydroxyethyl)phenyl]ethane-1,2-diol 在 barium hydroxide octahydrate 、 [Ir(benImi)3(CO)]BF₄ 作用下， 以 甲醇 为溶剂， 以74%的产率得到
  参考文献：
  名称：

  通过醇的催化交叉偶联模块化获得季 α-羟基乙酸酯

  摘要：

  α-羟基酸及其衍生物因其独特而广泛的功能而备受关注。在此，我们成功地建立了一个选择性和模块化的方案，通过使用三-N-杂环卡宾铱（tris-NHC-Ir，0.05 mol %）通过 1,2-二醇和伯醇的脱氢交叉偶联获得季 α-羟基乙酸酯)络合物作为催化剂和Ba(OH) 2作为碱，同时产生副产物水和氢气。提出了一种涉及醇脱氢、羟醛缩合和 1,2-烷基重排反应的合理机制，其中 1,2-烷基重排负责季碳中心的构建。

  DOI：

  10.1021/acscatal.2c05820

文献信息

• Urethane-crosslinked biodegradable elastomers
  申请人：Langer Robert S.

  公开号：US10035871B2

  公开（公告）日：2018-07-31

  Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B—)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.

  除其他外，本公开提供了一种弹性交联聚酯材料的组合物和方法。在某些实施例中，这种弹性交联聚酯材料包括通式（-A-B-）p 的多个聚合物单元，其中 p 是大于 1 的整数；以及多个聚氨酯交联剂，其中每个交联剂将两个聚合物单元彼此共价连接，这两个连接的聚合物单元在形成交联剂之前各自至少有一个游离羟基或氨基。
• POLYOL-BASED POLYMERS
  申请人：Bruggeman Joost P.

  公开号：US20110008277A1

  公开（公告）日：2011-01-13

  The present invention provides inventive polyol-based polymers, materials, pharmaceutical compositions, and methods of making and using the inventive polymers and materials. In certain aspects of the invention, an inventive polymer corresponds to a polymer depicted below. Exemplary inventive polymers includes those prepared using polyol units (e.g., xylitol, mannitol, sorbitol, or maltitol) condensed with polycarboxylic acid units (e.g., citric acid, glutaric acid, or sebacic acid). The inventive polymers may be further derivatized or modified. For example, the polymer may be made photocrosslinkable by adding methacrylate moieties to the polymer.
• URETHANE-CROSSLINKED BIODEGRADABLE ELASTOMERS
  申请人：Langer Robert S.

  公开号：US20130231412A1

  公开（公告）日：2013-09-05

  Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B—) p , wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.
• US8912304B2
  申请人：——

  公开号：US8912304B2

  公开（公告）日：2014-12-16
• [EN] POLYOL-BASED POLYMERS<br/>[FR] POLYMÈRES À BASE DE POLYOLS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2008144514A2

  公开（公告）日：2008-11-27

  [EN] The present invention provides inventive polyol-based polymers, materials, pharmaceutical compositions, and methods of making and using the inventive polymers and materials. In certain aspects of the invention, an inventive polymer corresponds to a polymer depicted below. Exemplary inventive polymers includes those prepared using polyol units (e.g., xylitol, mannitol, sorbitol, or maltitol) condensed with polycarboxylic acid units (e.g., citric acid, glutaric acid, or sebacic acid). The inventive polymers may be further derivatized or modified. For example, the polymer may be made photocrosslinkable by adding methacrylate moieties to the polymer.
  [FR] La présente invention concerne des polymères à base de polyols, des matériaux de ceux-ci, des compositions pharmaceutiques utilisant ceux-ci et des procédés de fabrication et d'utilisation des polymères et matériaux de l'invention. Dans certains aspects, l'invention concerne un polymère correspondant à un polymère décrit ci-dessous. Les polymères de l'invention donnés à titre d'exemple comprennent ceux préparés en utilisant des unités polyols (par exemple le xylitol, le mannitol, le sorbitol ou le maltitol) condensées avec des unités acides carboxyliques (par exemple l'acide citrique, l'acide glutarique ou l'acide sébacique). Les polymères de l'invention peuvent être en plus dérivés ou modifiés. Par exemple, le polymère peut être rendu réticulable en ajoutant des entités méthacrylates au polymère.