2-Hydroxy-6-[2-hydroxy-2-(8,9,10-trihydroxy-4,6-dimethyl-11-oxo-azacycloundec-2-yl)ethyl]benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Hydroxy-6-[2-hydroxy-2-(8,9,10-trihydroxy-4,6-dimethyl-11-oxo-azacycloundec-2-yl)ethyl]benzoic acid
• 英文别名: 2-hydroxy-6-[2-hydroxy-2-(8,9,10-trihydroxy-4,6-dimethyl-11-oxo-azacycloundec-2-yl)ethyl]benzoic acid
• 化学式: C₂₁H₃₁NO₈
• 分子量: 425.5
• InChiKey: IUWYFAJPWWGGKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  168
• 氢给体数：
  7
• 氢受体数：
  8

文献信息

• MACROCYCLIC AMIDES, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF
  申请人：Yang Chongren

  公开号：US20120238538A1

  公开（公告）日：2012-09-20

  Macrocyclic amide WH-21091 with antibacterial and antitumor activities, its analogs, preparation methods and uses thereof. The said macrocyclic amides are prepared by microbes of Xenorhabdus and Photorhabdus, or they can be prepared by other living beings through transgenic techniques. The compositions of the said macrocyclic amide and its analogs can be used as drugs and/or agricultural chemicals for treatment of microbial infections, especially for treatment of infectious diseases of Staphylococcus aureus with drug resistance. The said compositions can also be used as drugs for treatment of cancers of human beings or animals.
• US8680087B2
  申请人：——

  公开号：US8680087B2

  公开（公告）日：2014-03-25