Di-meta-hydroxyphenylglyoxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Di-meta-hydroxyphenylglyoxylic acid
• 英文别名: 3,5-Dihydroxyphenylglyoxylic acid；2-(3,5-dihydroxyphenyl)-2-oxoacetic acid
• 化学式: C₈H₆O₅
• 分子量: 182.133
• InChiKey: IXVSXZQERGYQTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (S)-3,5-二羟基苯基甘氨酸 在 p-hydroxyphenylglycine transaminase 磷酸吡哆醛 、 2-氧代-戊二酸离子(2-) 、 三羟甲基氨基甲烷盐酸盐 作用下， 反应 1.0h， 生成 Di-meta-hydroxyphenylglyoxylic acid
  参考文献：
  名称：

  Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin

  摘要：

  The biosynthetic pathway to the L-di-meta-hydroxyphenylglycine (DHPG) constituent of chloroeremomycin (A82846B), has been investigated by a combination of feeding experiments with 13C-labelled substrates, and expression and assay of HpgT from the chloroeremomycin biosynthetic cluster.

  DOI：

  10.1039/b103668h

文献信息

• Genes and proteins for the biosynthesis of the glycopeptide antibiotic A40926
  申请人：Vicuron Pharmaceuticals, Inc.

  公开号：EP1413626A1

  公开（公告）日：2004-04-28

  The present invention relates to the field of antibiotics and more specifically to the isolation of nucleic acid molecules that code for the biosynthetic pathway of the glycopeptide antibiotic A40926. Disclosed are the functions of the gene products involved in A40926 production. The present invention provides biosynthetic genes that code for A40926 production, the encoded polypeptides, the recombinant vectors comprising the nucleic acid sequences that encode said polypeptides, the host cells transformed with said vectors and methods for producing glycopeptide antibiotics using said transformed host cells, including methods for producing A40926, a precursor thereof, a derivative thereof or a modified glycopeptide different from A40926 or a precursor thereof.

  本发明涉及抗生素领域，更具体地说，涉及分离编码糖肽抗生素 A40926 生物合成途径的核酸分子。本发明公开了参与 A40926 生产的基因产物的功能。本发明提供了编码生产 A40926 的生物合成基因、编码的多肽、包含编码所述多肽的核酸序列的重组载体、用所述载体转化的宿主细胞以及使用所述转化的宿主细胞生产糖肽抗生素的方法，包括生产 A40926、其前体、其衍生物或不同于 A40926 或其前体的修饰糖肽的方法。
• Genes and proteins for the biosynthesis of the glycopeptide antibiotic teicoplanin
  申请人：Vicuron Pharmaceuticals, Inc.

  公开号：EP1460085A1

  公开（公告）日：2004-09-22

  The present invention relates to the field of antibiotics, and more specifically to the isolation of nucleic acid molecules that code for the biosynthetic pathway of the glycopeptide antibiotic teicoplanin. Disclosed are the functions of the gene products involved in teicoplanin production. The present invention provides novel biosynthetic genes that code for teicoplanin production, the encoded polypeptides, the recombinant vectors comprising the nucleic acid sequences that encode said polypeptides, the host cells transformed,with said vectors and methods for producing glycopeptide antibiotics using said transformed host cells, including methods for producing teicoplanin, a precursor thereof, a derivative thereof or a modified glycopeptide different from teicoplanin or a precursor thereof.

  本发明涉及抗生素领域，更具体地说，涉及分离编码糖肽类抗生素替考拉宁生物合成途径的核酸分子。本发明还公开了参与生产替考拉宁的基因产物的功能。本发明提供了编码生产替考拉宁的新型生物合成基因、编码的多肽、包含编码所述多肽的核酸序列的重组载体、用所述载体转化的宿主细胞以及使用所述转化的宿主细胞生产糖肽类抗生素的方法，包括生产替考拉宁、其前体、其衍生物或不同于替考拉宁或其前体的改良糖肽的方法。
• GENES AND PROTEINS FOR THE BIOSYNTHESIS OF THE GLYCOPEPTIDE ANTIBIOTIC A40926
  申请人：Vicuron Pharmaceuticals, Inc.

  公开号：EP1578972A2

  公开（公告）日：2005-09-28
• Genes and Proteins For the Biosynthesis of the Glycopeptide Antibiotic A40926
  申请人：Donadio Stefano

  公开号：US20080145892A1

  公开（公告）日：2008-06-19

  The present invention relates to the field of antibiotics, and more specifically to the isolation of nucleic acid molecules that code for the biosynthetic pathway of the glycopeptide antibiotic A40926. Disclosed are the functions of the gene products involved in A40926 production. The present invention provides biosynthetic genes that code for A40926 production, the encoded polypeptides, the recombinant vectors comprising the nucleic acid sequences that encode said polypeptides, the host cells transformed with said vectors and methods for producing glycopeptide antibiotics using said transformed host cells, including methods for producing A40926, a precursor thereof, a derivative thereof or a modified glycopeptide different from A 40926 or a precursor thereof.
• [EN] GENES AND PROTEINS FOR THE BIOSYNTHESIS OF THE GLYCOPEPTIDE ANTIBIOTIC A40926<br/>[FR] GENES ET PROTEINES POUR LA BIOSYNTHESE DE L'ANTIBIOTIQUE GLYCOPEPTIDE A40926
  申请人：VICURON PHARM INC

  公开号：WO2004038025A2

  公开（公告）日：2004-05-06

  The present invention relates to the field of antibiotics, and more specifically to the isolation of nucleic acid molecules that code for the biosynthetic pathway of the glycopeptide antibiotic A40926. Disclosed are the functions of the gene products involved in A40926 production. The present invention provides biosynthetic genes that code for A40926 production, the encoded polypeptides, the recombinant vectors comprising the nucleic acid sequences that encode said polypeptides, the host cells transformed with said vectors and methods for producing glycopeptide antibiotics using said transformed host cells, including methods for producing A40926, a precursor thereof, a derivative thereof or a modified glycopeptide different from A 40926 or a precursor thereof.