3-(2-Hydroxy-4-methoxy-6-methylphenoxy)-5-methylcatechol | 115103-30-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-Hydroxy-4-methoxy-6-methylphenoxy)-5-methylcatechol
• 英文别名: 3-(2-hydroxy-4-methoxy-6-methylphenoxy)-5-methylbenzene-1,2-diol
• CAS: 115103-30-5
• 化学式: C₁₅H₁₆O₅
• 分子量: 276.28
• InChiKey: JGXPRDVSWGDODG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment
  申请人：Indiana University Research and Technology Corporation

  公开号：US11034689B2

  公开（公告）日：2021-06-15

  Provided are compounds of formulas (I), (II), (III), and (IV), which effectively inhibit protein arginine methyltransferase 5 (PRMT5). Also provided are methods of using the compounds, including a method of treating cancer, a method of inhibiting the activity of PRMT5 in a cell, and a method of treating a disease associated with increased activity of PRMT5.

  本发明提供了式(I)、(II)、(III)和(IV)化合物，它们能有效抑制蛋白精氨酸甲基转移酶 5 (PRMT5)。还提供了使用这些化合物的方法，包括治疗癌症的方法、抑制细胞中 PRMT5 活性的方法，以及治疗与 PRMT5 活性增加有关的疾病的方法。
• Small Molecule Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors and Methods of Treatment
  申请人：INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

  公开号：US20200062745A1

  公开（公告）日：2020-02-27

  Provided are compounds of formulas (I), (II), (III), and (IV), which effectively inhibit protein arginine methyltransferase 5 (PRMT5). Also provided are methods of using the compounds, including a method of treating cancer, a method of inhibiting the activity of PRMT5 in a cell, and a method of treating a disease associated with increased activity of PRMT5.