2,4-bis(benzoylamino)pyrimidine | 1379786-98-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-bis(benzoylamino)pyrimidine
• 英文别名: 2,4-bis-(benzamido)pyrimidine；N-(2-benzamidopyrimidin-4-yl)benzamide
• CAS: 1379786-98-7
• 化学式: C₁₈H₁₄N₄O₂
• 分子量: 318.335
• InChiKey: CCRAWGSIIFSTLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,6-二氨基吡啶 、 苯甲酸酐 以87%的产率得到2,4-bis(benzoylamino)pyrimidine
  参考文献：
  名称：

  氨基尿嘧啶的脯氨酰胺，可通过互补模块修饰的有机催化剂

  摘要：

  带有氨基尿嘧啶的脯氨酰胺有机催化剂具有增强的NH酸度，额外的氢键供体以及通过沃森-克里克配对与互补模块自组装的特点。每个模块都会影响反应的选择性，特别是2,6-二氨基吡啶对反应的选择性有益。

  DOI：

  10.1002/ejoc.201800886

文献信息

• POLYMER FILM, RETARDATION FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY, AND COMPOUND
  申请人：FUJIFILM Corporation

  公开号：US20160159750A1

  公开（公告）日：2016-06-09

  Provided is a polymer film containing at least one of a compound represented by formula (1) of hydrates, solvates, or salts thereof. Y is a methine group or nitrogen atom. Q a , Q b , and Q c are a single bond or a divalent linking group. R a , R b , and R c , are hydrogen atom, alkyl group, alkenyl group, alkynyl group, aryl group, cyano group, halogen group, or heterocyclic group. X 2 is a single bond or a divalent linking group. X 1 is a single bond or a predetermined divalent linking group. R 1 and R 2 are a hydrogen atom, alkyl group, alkenyl group, alkynyl group, aryl group, or heterocyclic group Formula (1)

  提供的是一种聚合物薄膜，其中至少包含一种由式（1）表示的化合物的水合物、溶剂合物或盐类。Y是一个亚甲基基团或氮原子。Qa、Qb和Qc是单键或二价连接基团。Ra、Rb和Rc是氢原子、烷基基团、烯基基团、炔基基团、芳基、氰基、卤素基或杂环基。X2是单键或二价连接基团。X1是单键或预定的二价连接基团。R1和R2是氢原子、烷基基团、烯基基团、炔基基团、芳基或杂环基。Formula (1)
• Synthesis of 4-Aminophthalimide and 2,4-Diaminopyrimidine <i>C</i>-Nucleosides as Isosteric Fluorescent DNA Base Substitutes
  作者：Michael Weinberger、Falko Berndt、Rainer Mahrwald、Nikolaus P. Ernsting、Hans-Achim Wagenknecht

  DOI：10.1021/jo302768f

  日期：2013.3.15

  be further processed to the corresponding phosphoramidite as DNA building blocks that allow incorporation of these chromophores as artificial DNA bases by automated DNA synthesis. The combination of the poor stacking properties of 1 and the hydrogen bonding interface at the phthalimide functionality that does not fit to any of natural DNA bases in the counterstrand yields destabilization of the duplex

  4 aminophthalimide C-核苷1被设计为一个等量DNA碱基替代，以及合成路线核苷1与2,4-二氨基嘧啶-C-核苷一起2作为一个潜在的counterbase被制定。两种合成途径中的关键步骤均代表与2'-脱氧核糖呋喃糖苷糖基的立体选择性Heck型钯催化的交叉偶联，然后由NaBH（OAc）3进行立体选择性还原。核苷1在高极性和具有氢键合能力的溶剂中显示出溶剂化荧光色行为和明显的红移荧光。核苷1和2可以进一步加工成相应的亚磷酰胺作为DNA构建基块，从而可以通过自动DNA合成将这些生色团作为人工DNA碱基掺入。1的较差堆积特性和邻苯二甲酰亚胺官能团上的氢键键合界面（不适合反链中的任何天然DNA碱基）的组合会导致双链体在4-11°C时不稳定。代表性双链DNA中1的荧光特征是较大的斯托克斯位移和约12％的量子产率。考虑到发色团的尺寸非常小，这些都是非凡的光学性质，表明这些核苷类似物在荧光DNA分析和成像中具有很高的潜力。
• CELLULOSE ACYLATE FILM, RETARDATION FILM, POLARIZER AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：NAGURA MASATO

  公开号：US20110076423A1

  公开（公告）日：2011-03-31

  A cellulose acylate film comprising a cellulose acylate resin satisfying the formulae (i)-(iii) and a compound capable of forming a hydrogen bond satisfying conditions (A)-(C): (A) the compound has both a hydrogen bond donor moiety and a hydrogen bond acceptor moiety in the molecule, (B) the value obtained by dividing the molecular weight of the compound by the total of the number of the hydrogen bond donor moiety and the number of the hydrogen bond acceptor moiety is from 30 to 65, (C) the number of aromatic ring structures is from 1 to 3, 0.5≦ A+B ≦2.7,  (i) 0.0≦A≦2.5, and  (ii) 0.1≦B≦2.0,  (iii) wherein A means the degree of substitution with an acetyl group, and B means a total of the degree of substitution with a propionyl group and the degree of substitution with a butyryl group.
• Optical film, retardation film, polarizing plate, and liquid crystal display device
  申请人：Sasada Yasuyuki

  公开号：US20120018685A1

  公开（公告）日：2012-01-26

  An optical film contains a cellulose ester and more than 30% by mass, relative to the cellulose ester, of a condensation product of at least one polyhydric alcohol having an average of 2.01 or more carbon atoms and at least one polybasic acid having an average of 4.10 or more carbon atoms, and at least one of the at least one polyhydric alcohol contains at least three carbon atoms bonded together without being interrupted by any other atom.
• Cellulose Acylate Film, Retardation Film, Polarizer and Liquid Crystal Display Device
  申请人：Nagura Masato

  公开号：US20120204757A1

  公开（公告）日：2012-08-16

  A cellulose acylate film comprising a cellulose acylate resin satisfying the formulae (i)-(iii) and a compound capable of forming a hydrogen bond satisfying conditions (A)-(C): (A) the compound has both a hydrogen bond donor moiety and a hydrogen bond acceptor moiety in the molecule, (B) the value obtained by dividing the molecular weight of the compound by the total of the number of the hydrogen bond donor moiety and the number of the hydrogen bond acceptor moiety is from 30 to 65, (C) the number of aromatic ring structures is from 1 to 3, 0.5≦ A+B ≦2.7,  (i) 0.0≦ A ≦2.5, and  (ii) 0.1≦ B ≦2.0,  (iii) wherein A means the degree of substitution with an acetyl group, and B means a total of the degree of substitution with a propionyl group and the degree of substitution with a butyryl group.