3-(4-Isopropoxyphenyl)-3-(2-methoxyphenyl)propionitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-Isopropoxyphenyl)-3-(2-methoxyphenyl)propionitrile
• 英文别名: 3-(2-methoxyphenyl)-3-(4-propan-2-yloxyphenyl)propanenitrile
• 化学式: C₁₉H₂₁NO₂
• 分子量: 295.381
• InChiKey: JJPINWWEZNDKRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  42.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(4-Isopropoxyphenyl)-3-(2-methoxyphenyl)propionitrile 在 potassium hydroxide 作用下， 反应 6.0h， 以88%的产率得到3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionic acid
  参考文献：
  名称：

  Synthesis of 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionamides

  摘要：

  Hydrolysis of 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionitrile results in 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionic acid, which after reaction with thionyl chloride is turned into acylchloride. By acylation of a number of amines by 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionyl chloride, synthesized the corresponding propionamides. The results of biological tests showed that the obtained compounds possess week antibacterial activity.

  DOI：

  10.1134/s1070363214110073

文献信息

• Synthesis of 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionamides
  作者：N. S. Arutyunyan、O. A. Papoyan、L. A. Akopyan、R. V. Paronikyan、G. A. Panosyan、G. A. Gevorgyan

  DOI：10.1134/s1070363214110073

  日期：2014.11

  Hydrolysis of 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionitrile results in 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionic acid, which after reaction with thionyl chloride is turned into acylchloride. By acylation of a number of amines by 3-(4-isopropoxyphenyl)-3-(2-methoxyphenyl)propionyl chloride, synthesized the corresponding propionamides. The results of biological tests showed that the obtained compounds possess week antibacterial activity.