Retamin | 27804-79-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 羽扇豆生物碱
• 英文名称: Retamin
• 英文别名: 12e-Hydroxy-α-isospartein；Retamine；7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecan-3-ol
• CAS: 27804-79-1
• 化学式: C₁₅H₂₆N₂O
• 分子量: 250.384
• InChiKey: JMXNBIDTNISOTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.7
• 氢给体数：
  1
• 氢受体数：
  3

ADMET

代谢

雷特胺是麻黄碱的一个已知的人类代谢物。

Retamine is a known human metabolite of sparteine.

来源:NORMAN Suspect List Exchange

文献信息

• COMPOSITIONS AND METHODS EMPLOYING NMDA ANTAGONISTS FOR ACHIEVING AN ANESTHETIC-SPARING EFFECT
  申请人：Eppler Cecil Mark

  公开号：US20090061024A1

  公开（公告）日：2009-03-05

  Provided herein are compositions, combinations, and methods comprising NMDA antagonists including, but not limited to, NMDA glutamate receptor antagonists such as [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1-(7)-en-2-yl)alkyl]phosphonic acid and derivatives thereof, which are effective in reducing the amount of anesthetic required to maintain anesthesia (i.e. to achieve an anesthetic-sparing effect).

  本文提供包括NMDA拮抗剂在内的组合物、配方和方法，其中NMDA谷氨酸受体拮抗剂如[2-(8,9-二氧杂-2,6-二氮杂双环[5.2.0]非-1-(7)-烯-2-基)烷基]膦酸及其衍生物等，能够有效地减少维持麻醉所需的麻醉剂量（即实现麻醉节约效应）。
• System and method for guidance of anesthesia, analgesia and amnesia
  申请人：——

  公开号：US20040079372A1

  公开（公告）日：2004-04-29

  A method for monitoring anesthetization of a patient, includes the steps of removably connecting a plurality of electrodes to the scalp of the patient and administering sufficient anesthesia to the patient so that the patient attains a plane of anesthesia selected by an operator. The brain waves of the patient are then amplified and digitized after the patient has been anesthetized, before beginning the medical procedure, to obtain a first set of digital data. The brain waves of the patient are then amplified and digitized during the medical procedure to provide a second set of digital data and the first and second sets of digital data are analyzed in at least one of a time domain and a frequency domain. Separate trajectories are then computed from the data analysis trajectories for at least two different indices of an anesthetic state of the patient during the medical procedure, the indices being selected from a group including a Depth Index (DI), a Memory Index (MI) and a Pain Index (PI). A system for providing anesthesia to a patient, includes a plurality of electrodes, a first arrangement allowing an operator to administer anesthesia to the patient until the patient has attained a selected plane of anesthesia and a second arrangement coupled to the electrodes for amplifying and digitizing brain waves of the patient after the patient has been anesthetized, before the medical procedure has been begun to obtain a first set of digital data, the second arrangement amplifying and digitizing ongoing brain waves of the patient during the medical procedure to provide a second set of digital data in combination with a third arrangement analyzing the first and second sets of digital data in at least one of a time domain and a frequency domain, a fourth arrangement computing from the data analysis separate trajectories for at least two different indices of a state of the patient during the medical procedure, the indices being selected from a group including a Depth Index (DI), a Memory Index (MI) and a Pain Index (PI), a fifth arrangement providing control signals when any of the trajectories indicates that the patient is deviating from the selected plane of anesthesia and a sixth arrangement automatically adjusting two different anesthetic agents administered to the patient based on the control signal to restore the patient to the selected plane of anesthesia.

  一种监测病人麻醉情况的方法，包括以下步骤：将多个电极可移动地连接到病人的头皮上，并对病人进行充分麻醉，使病人达到操作员选定的麻醉平面。然后，在病人被麻醉后，在医疗程序开始前，对病人的脑电波进行放大和数字化处理，以获得第一组数字数据。然后在医疗过程中对病人的脑电波进行放大和数字化处理，以提供第二组数字数据，并在时域和频域中的至少一个域对第一组和第二组数字数据进行分析。然后从数据分析轨迹中计算出医疗过程中患者麻醉状态的至少两个不同指数的单独轨迹，这些指数选自包括深度指数（DI）、记忆指数（MI）和疼痛指数（PI）在内的一组指数。一种为病人提供麻醉的系统，包括多个电极，第一布置允许操作员对病人实施麻醉，直到病人达到选定的麻醉平面，第二布置与电极耦合，用于在病人被麻醉后放大病人的脑电波并将其数字化、在医疗过程开始前，第二装置放大和数字化患者在医疗过程中的持续脑电波，以提供第二组数字数据，结合第三装置在时域和频域中的至少一个对第一组和第二组数字数据进行分析、第四种装置从数据分析中计算出医疗过程中患者状态的至少两种不同指数的单独轨迹，这些指数选自包括深度指数（DI）、记忆指数（MI）和疼痛指数（PI）在内的一组指数；第五种装置在任何轨迹表明患者偏离所选麻醉平面时提供控制信号；第六种装置根据控制信号自动调整给患者施用的两种不同麻醉剂，以使患者恢复到所选麻醉平面。
• KERATINOCYTE GROWTH FACTOR-2
  申请人：HUMAN GENOME SCIENCES, INC.

  公开号：EP1357931A2

  公开（公告）日：2003-11-05
• ANTI-TUMOR DRUG, MEDICAMENT, COMPOSITION, AND USE THEREOF
  申请人：GENE SIGNAL INTERNATIONAL SA

  公开号：EP2158317A1

  公开（公告）日：2010-03-03
• System and Method for Guidance of Anesthesia, Analgesia and Amnesia
  申请人：John Erwin R.

  公开号：US20100224188A1

  公开（公告）日：2010-09-09

  A system and method includes administering interventional agents to Patient until Patient attains a predetermined plane of anesthesia; amplifying and digitizing brain waves of Patient before and after administering step to generate first set of digital data; amplifying and digitizing brain waves of Patient during a medical procedure to generate second set of digital data; computing separate trajectories for at least two different indices of an anesthetic state of Patient during the medical procedure using a comparison of first and second sets (the indices including Depth Index (DI)—a depth of anesthesia, Memory Index (MI)—an ability to form and store memories, and Pain Index (PI)—sensitivity to pain); and determining an amount of at least one of the interventional agents to be delivered to Patient as a function of the trajectories, the interventional agents include anesthetic, analgesic and/or amnesic agents corresponding to DI, MI and/or PI trajectories.