6-Methoxy-2-butyl-tetralon-(1) | 52923-88-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 6-Methoxy-2-butyl-tetralon-(1)
• 英文别名: 2-butyl-6-methoxy-3,4-dihydro-1(2H)-naphthalenone；2-butyl-6-methoxy-3,4-dihydro-2H-naphthalen-1-one
• CAS: 52923-88-3
• 化学式: C₁₅H₂₀O₂
• 分子量: 232.323
• InChiKey: DTDOPUQZGWXJSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-Methoxy-2-butyl-tetralon-(1) 在 氢碘酸 、 sulfur 、 溶剂黄146 作用下， 生成 6-Hydroxy-1-ethyl-2-butyl-naphthalin
  参考文献：
  名称：

  Buchta,E.; Schaefer,C.W., Chemische Berichte, 1964, vol. 97, p. 1308 - 1317

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate 在 盐酸 、 溶剂黄146 作用下， 生成 6-Methoxy-2-butyl-tetralon-(1)
  参考文献：
  名称：

  Buchta,E.; Schaefer,C.W., Chemische Berichte, 1964, vol. 97, p. 1308 - 1317

  摘要：

  DOI：

文献信息

• Estrogen receptor modulators
  申请人：Parker LeRoy Dann

  公开号：US20060041003A1

  公开（公告）日：2006-02-23

  The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Pagets disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

  本发明涉及化合物及其衍生物，它们的合成以及它们作为雌激素受体调节剂的用途。本发明的化合物是雌激素受体的配体，因此可用于治疗或预防与雌激素功能相关的各种疾病，包括：骨质流失、骨折、骨质疏松症、转移性骨病、帕吉特病、牙周病、软骨退化、子宫内膜异位症、子宫肌瘤病、潮热、低密度脂蛋白胆固醇水平升高、心血管疾病、认知功能障碍、脑退行性疾病、再狭窄、男性乳腺发育、血管平滑肌细胞增殖、肥胖、失禁以及癌症，特别是乳腺、子宫和前列腺癌。
• ESTROGEN RECEPTOR MODULATORS
  申请人：Merck & Co., Inc.

  公开号：EP1551820A2

  公开（公告）日：2005-07-13
• US7432284B2
  申请人：——

  公开号：US7432284B2

  公开（公告）日：2008-10-07
• [EN] ESTROGEN RECEPTOR MODULATORS<br/>[FR] MODULATEURS DES RECEPTEURS DES OESTROGENES
  申请人：MERCK & CO INC

  公开号：WO2004026887A2

  公开（公告）日：2004-04-01

  The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget s disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.