(3-Benzyloxy-phenyl)-[4-(5-methyl-3-methylsulfanyl-1-pyridin-2-yl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine | 475574-52-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (3-Benzyloxy-phenyl)-[4-(5-methyl-3-methylsulfanyl-1-pyridin-2-yl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine
• 英文别名: 4-(5-methyl-3-methylsulfanyl-1-pyridin-2-ylpyrazol-4-yl)-N-(3-phenylmethoxyphenyl)pyrimidin-2-amine
• CAS: 475574-52-8
• 化学式: C₂₇H₂₄N₆OS
• 分子量: 480.593
• InChiKey: FCVSPYXNZPPFRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-dimethylamino-1-(5-methyl-3-methylsulfanyl-1-pyridin-2-yl-1 H-pyrazol-4-yl)-propenone 、 2-(3-苯基甲氧基苯基)胍 以 乙酸乙酯 为溶剂， 以40%的产率得到(3-Benzyloxy-phenyl)-[4-(5-methyl-3-methylsulfanyl-1-pyridin-2-yl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine
  参考文献：
  名称：

  Inhibitors of Src and other protein kinases

  摘要：

  本发明提供了式I的化合物： 其中A为N或CR，而G、R1、R2和R3如规范中所述。这些化合物是蛋白激酶的抑制剂，特别是涉及细胞增殖、细胞死亡和对细胞外刺激反应的哺乳动物Src蛋白激酶的抑制剂。该发明还涉及制备这些抑制剂的方法。该发明还提供了包括该发明的抑制剂的药物组合物以及利用这些组合物在治疗和预防各种疾病中的方法。

  公开号：

  US20030144309A1

文献信息

• HETEROCYCLIC SUBSTITUTED PYRAZOLES AS INHIBITORS OF SRC AND OTHER PROTEIN KINASES
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1404669A2

  公开（公告）日：2004-04-07
• US6884804B2
  申请人：——

  公开号：US6884804B2

  公开（公告）日：2005-04-26
• [EN] INHIBITORS OF SRC AND OTHER PROTEIN KINASES<br/>[FR] INHIBITEURS DE SRC ET AUTRES PROTEINE KINASES
  申请人：VERTEX PHARMA

  公开号：WO2002092573A2

  公开（公告）日：2002-11-21

  The present invention provides compounds of formula I:wherein A is N or CR, and G, R1, R2, and R3 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of Src mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
• Inhibitors of Src and other protein kinases
  申请人：——

  公开号：US20030144309A1

  公开（公告）日：2003-07-31

  The present invention provides compounds of formula I: 1 wherein A is N or CR, and G, R 1 , R 2 and R 3 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of Src mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

  本发明提供了式I的化合物： 其中A为N或CR，而G、R1、R2和R3如规范中所述。这些化合物是蛋白激酶的抑制剂，特别是涉及细胞增殖、细胞死亡和对细胞外刺激反应的哺乳动物Src蛋白激酶的抑制剂。该发明还涉及制备这些抑制剂的方法。该发明还提供了包括该发明的抑制剂的药物组合物以及利用这些组合物在治疗和预防各种疾病中的方法。