N-(3,4-Dimethoxy-2-chlorobenzylideneamino)guanidine | 284042-43-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,4-Dimethoxy-2-chlorobenzylideneamino)guanidine
• 英文别名: 2-[(E)-(2-chloro-3,4-dimethoxyphenyl)methylideneamino]guanidine
• CAS: 284042-43-9
• 化学式: C₁₀H₁₃ClN₄O₂
• 分子量: 256.69
• InChiKey: FGEWTNKUNGVHKT-LHHJGKSTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] METHOD OF TREATING CANCER WITH A COMBINATION OF BENZYLIDENEGUANIDINE DERIVATIVES AND CHEMOTHERAPEUTIC AGENT.<br/>[FR] PROCÉDÉ DE TRAITEMENT DE CANCER AVEC UNE COMBINAISON DE DÉRIVÉS DE BENZYLIDÈNEGUANIDINE ET D'AGENT CHIMIOTHÉRAPEUTIQUE
  申请人：INFLECTIS BIOSCIENCE

  公开号：WO2017021216A1

  公开（公告）日：2017-02-09

  The present invention relates to a composition for use in treating a glioma or ameliorating the effects of a glioma, particularly glioblastoma, wherein said composition comprises a first active agent selected from the group consisting of a compound of formula (I), or a pharmaceutically acceptable salt thereof, (I) and a second active agent, which is temozolomide, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

  本发明涉及一种用于治疗胶质瘤或改善胶质瘤效果，特别是胶质母细胞瘤的组合物，所述组合物包括选自以下化合物组的第一活性剂，即化合物(I)或其药学上可接受的盐(I)，以及第二活性剂，即替莫唑胺或其药学上可接受的盐；以及一种药学上可接受的载体。
• [EN] O-ALKYL-BENZYLIDENEGUANIDINE DERIVATIVES AND THERAPEUTIC USE FOR THE TREATMENT OF DISORDERS ASSOCIATED AN ACCUMULATION OF MISFOLDED PROTEINS<br/>[FR] DÉRIVÉS D'O-ALKYL-BENZYLIDÈNEGUANIDINE ET LEUR UTILISATION THÉRAPEUTIQUE POUR LE TRAITEMENT DE TROUBLES ASSOCIÉS À UNE ACCUMULATION DE PROTÉINES MAL REPLIÉES
  申请人：INFLECTIS BIOSCIENCE

  公开号：WO2016001390A1

  公开（公告）日：2016-01-07

  The present invention relates to a compound of formula (I), or a tautomer and/or a pharmaceutically acceptable salt thereof Formula (I), and its uses to treat a disorder associated with protein misfolding stress and in particular with an accumulation of misfolded proteins.

  本发明涉及公式(I)的化合物，或其互变异构体和/或药用可接受的盐，以及其用于治疗与蛋白质错误折叠应激有关的疾病，特别是与错误折叠蛋白的积累有关的用途。
• NOVEL 5-HT2 ANTAGONISTS
  申请人：AnaMar AB

  公开号：EP3109237A1

  公开（公告）日：2016-12-28

  The present invention relates to 1-amidino-3-aryl-2-pyrazoline derivatives of the general formula I The invention specifically relates to such derivatives which exhibit antagonizing activity towards serotonin 5-HT2B receptors. The present invention also relates to use of said compounds as a medicament and for the treatment of fibrosis, cardiovascular diseases, pain, IBD, and other inflammatory diseases, as well as pharmaceutical compositions comprising one or more of said compounds and methods of treatment.

  本发明涉及通式I的1-酰胺基-3-芳基-2-吡唑啉衍生物。该发明具体涉及表现出对5-HT2B受体具有拮抗活性的这类衍生物。本发明还涉及将所述化合物用作药物以及用于治疗纤维化、心血管疾病、疼痛、炎症性肠病和其他炎症性疾病的用途，以及包含一种或多种所述化合物的药物组合物和治疗方法。
• [EN] NOVEL THERAPEUTIC USES OF BENZYLIDENEGUANIDINE DERIVATIVES FOR THE TREATMENT OF PROTEOPATHIES<br/>[FR] NOUVELLES UTILISATIONS THÉRAPEUTIQUES DE DÉRIVÉS DE LA BENZYLIDÈNE-GUANIDINE DANS LE TRAITEMENT DE PROTÉOPATHIES
  申请人：INFLECTIS BIOSCIENCE

  公开号：WO2016001389A1

  公开（公告）日：2016-01-07

  The present invention relates to novel uses of a compound of formula (I), or a tautomer and/or a pharmaceutically acceptable salt thereof, in treating a disorder associated with the PPP1R15A pathway and associated with protein misfolding stress and in particular with accumulation of misfolded proteins selected in the group of tauopathies, synucleinopathies, polyglutamine and polyalanine diseases, leukodystrophies, cystic fibrosis, multiple sclerosis, lysosomal storage disorders, amyloidosis diseases, inflammation, metabolic disorders, cardio-vascular disorders, osteoporosis, nervous system trauma, ischemia.

  本发明涉及一种化合物（I）的新用途，或其互变异构体和/或药用盐，在治疗与PPP1R15A途径相关的紊乱，与蛋白质错误折叠应激相关，特别是与在tau病、α-突触核蛋白病、多聚谷氨酸和多聚丙氨酸疾病、白质病、囊性纤维化、多发性硬化、溶酶体贮积疾病、淀粉样变性疾病、炎症、代谢紊乱、心血管疾病、骨质疏松症、神经系统创伤、缺血等相关的错误折叠蛋白的积累。
• COMPOUNDS FOR TREATMENTS OF INFLAMMATION
  申请人：Palmqvist Niklas

  公开号：US20120190751A1

  公开（公告）日：2012-07-26

  The present invention relates to the use of benzylideneaminoguanidines for the treatment of inflammation and pain. In one preferred embodiment, the invention relates to the use of N-(2-chloro-3,4-dimethoxybenzylideneamino)guanidine for the treatment of rheumatoid arthritis.

  本发明涉及使用苯甲醛胍基胍类化合物治疗炎症和疼痛。在一个优选实施例中，本发明涉及使用N-(2-氯-3,4-二甲氧基苯甲醛基)胍基胍治疗类风湿性关节炎。