5,8,12,14,20,23,27,28-octahydroxy-6,21-dimethyloctacyclo[14.11.1.0²,¹¹.0²,¹⁵.0⁴,⁹.0¹³,¹⁷.0¹⁷,²⁶.0¹⁹,²⁴]octacosa-4(9),5,7,11,19(24),20,22,26-octaene-3,10,18,25-tetrone

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 5,8,12,14,20,23,27,28-octahydroxy-6,21-dimethyloctacyclo[14.11.1.0²,¹¹.0²,¹⁵.0⁴,⁹.0¹³,¹⁷.0¹⁷,²⁶.0¹⁹,²⁴]octacosa-4(9),5,7,11,19(24),20,22,26-octaene-3,10,18,25-tetrone
• 化学式: C30H22O12
• InChiKey: KXNUPFFSGSRABD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.42
• 重原子数：
  42.0
• 可旋转键数：
  0.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  230.12
• 氢给体数：
  8.0
• 氢受体数：
  12.0

文献信息

• Endophyte enhanced seedlings with increased pest tolerance
  申请人：IRVING LICENSING, INC.

  公开号：US10674699B2

  公开（公告）日：2020-06-09

  The invention provides methods for preparing a conifer seedling with increased tolerance to a pest. A conifer seedling is inoculated with an isolated endophyte when the conifer seedling is susceptible to colonization by the endophyte.

  本发明提供了制备对害虫耐受性增强的针叶树苗的方法。当针叶树苗易受内生菌定植时，用分离的内生菌接种针叶树苗。
• Pharmaceuticals and apparatus providing diagnosis and selective tissue necrosis
  申请人：——

  公开号：US20020051751A1

  公开（公告）日：2002-05-02

  Pharmaceuticals and Apparatus used in combination for diagnosis and tissue necrosis applicable to provide effective and selective therapy using the Mossbauer absorption phenomenon. Selected pharmaceutical compounds containing a radiation absorber isotope are administered to a tissue and excited by a radiation source which provides energy at the corresponding resonant Mossbauer absorption frequency of isotope containing pharmaceutical, where excitation effects nuclear transitions to cause highly selective energy absorption in the selected target tissue. For diagnostic purposes, de-excitation fluorescence of the isotope is monitored. For therapeutic purposes, the energy is converted to particle radiation by the isotope at the target tissue by internal conversion followed by an Auger electron cascade which results in radiolysis of DNA resulting in lethal double strand breaks in the DNA molecules of the target tissue. The tissue selectivity is achieved by providing a Mossbauer absorption frequency of the target tissue which differs from that of surrounding tissue. The difference in frequency is due to the properties of the pharmaceutical, and/or an imposition of external magnetic fields or narrow beam ultrasonic power at the site of the target tissue. The magnitude of radiation absorption at the resonant Mossbauer frequency for the target tissue is of the order of one million times the absorption of surrounding nontarget tissue, which has a different Mossbauer absorption frequency, thereby producing considerably reduced side effects in comparison to conventional chemotherapy or radiation therapy.

  用于诊断和组织坏死的药物和仪器组合，可利用莫斯鲍尔吸收现象提供有效的选择性治疗。将选定的含有辐射吸收同位素的药物化合物施用到组织中，并由辐射源激发，辐射源以含有药物同位素的相应共振莫斯鲍尔吸收频率提供能量，激发效应产生核转变，导致选定的靶组织高度选择性地吸收能量。为诊断目的，可监测同位素的去激发荧光。为达到治疗目的，同位素在靶组织中通过内部转换将能量转化为粒子辐射，然后产生奥杰电子级联，导致 DNA 放射性分解，造成靶组织 DNA 分子中致命的双链断裂。组织选择性是通过提供靶组织与周围组织不同的莫斯鲍尔吸收频率来实现的。频率的差异是由于药物的特性和/或在靶组织部位施加外部磁场或窄波束超声波功率造成的。靶组织在共振莫斯鲍尔频率上的辐射吸收量是周围非靶组织吸收量的一百万倍，而周围非靶组织的莫斯鲍尔吸收频率不同，因此与传统化疗或放疗相比，副作用大大降低。
• System and method for providing localized Mössbauer absorption in an organic medium
  申请人：Mills, Randell L.

  公开号：EP0316440B1

  公开（公告）日：1996-01-03
• ENDOPHYTE ENHANCED SEEDLINGS WITH INCREASED PEST TOLERANCE
  申请人：J.D. Irving, Limited

  公开号：EP2069499A2

  公开（公告）日：2009-06-17
• PRODUCTION OF MONASCUS-LIKE AZAPHILONE PIGMENT
  申请人：DTU, Technical University Of Denmark

  公开号：EP2262862A2

  公开（公告）日：2010-12-22