2-(tridecyl)furan | 25346-22-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-(tridecyl)furan
• 英文别名: 2-Tridecylfuran
• CAS: 25346-22-9
• 化学式: C₁₇H₃₀O
• 分子量: 250.425
• InChiKey: LFPGJDSJDXWCIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  18
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• LIPIDIC FURAN, PYRROLE, AND THIOPHENE COMPOUNDS FOR USE IN THE TREATMENT OF ATROPHIC VAGINITIS
  申请人：Avoscience, LLC

  公开号：US20170312246A1

  公开（公告）日：2017-11-02

  Provided herein are lipidic furan, pyrrole, and thiophene compounds, compositions, and methods using such compounds and compositions for the treatment of atrophic vaginitis. Specifically, the invention includes administering an effective amount of a compound of Formula I, I′, or I″, or a pharmaceutically acceptable composition, salt, isotopic analog, prodrug, or combination thereof, to a subject suffering from atrophic vaginitis.

  本文提供了脂质类呋喃、吡咯和噻吩化合物、组合物以及使用这些化合物和组合物治疗萎缩性阴道炎的方法。具体而言，本发明包括向患有萎缩性阴道炎的受试者投与化合物I、I'或I"的有效量，或者药学上可接受的组合物、盐、同位素类似物、前药或其组合物。
• Lipidic Furan, Pyrrole, and Thiophene Compounds for Treatment of Cancer, Neurological Disorders, and Fibrotic Disorders
  申请人：Avoscience, LLC

  公开号：US20140309274A1

  公开（公告）日：2014-10-16

  Compounds, methods, and compositions are provided for the treatment of cancer, neurological disorders, and fibrotic disorders. Specifically, the invention includes administering an effective amount of a compound of Formula I, II, or III, or a pharmaceutically acceptable composition, salt, isotopic analog, prodrug, or combination thereof, to a subject suffering from a cancer, neurological disorder, or fibrotic disorder.

  本发明提供了用于治疗癌症、神经系统疾病和纤维化疾病的化合物、方法和组合物。具体而言，该发明包括向患有癌症、神经系统疾病或纤维化疾病的受试者施用公式I、II或III的化合物、药学上可接受的组合物、盐、同位素类似物、前药或其组合的有效量。
• LIPIDIC FURAN, PYRROLE, AND THIOPHENE COMPOUNDS FOR TREATMENT OF CANCER, NEUROLOGICAL DISORDERS, AND FIBROTIC DISORDERS
  申请人：Avoscience, LLC

  公开号：US20160263080A1

  公开（公告）日：2016-09-15

  Compounds, methods, and compositions are provided for the treatment of cancer, neurological disorders, and fibrotic disorders. Specifically, the invention includes administering an effective amount of a compound of Formula I, II, or III, or a pharmaceutically acceptable composition, salt, isotopic analog, prodrug, or combination thereof, to a subject suffering from a cancer, neurological disorder, or fibrotic disorder.

  本发明提供了用于治疗癌症、神经系统疾病和纤维化疾病的化合物、方法和组合物。具体而言，本发明包括向患有癌症、神经系统疾病或纤维化疾病的受试者施用公式I、II或III的化合物或其药学上可接受的组合物、盐、同位素类似物、前药或其组合物的有效量。
• Novel lipidic furans useful for skin therapeutics
  申请人：Huber, S. Richard

  公开号：EP0775480A1

  公开（公告）日：1997-05-28

  A composition of matter useful for enhancing the metabolism of the skin and mucosal tissue and thereby improving its health and appearance. The composition of matter has the furan (2) - R, wherein R is a straight C9-36 alkyl chain, having the formula CH3-(CH2)n-(CH2) nCH3, (n = 8 to 35). R can also be a straight unsaturated C9-36 alkenyl chain with a single double bond, of the formula -(CH2)n-CH=CH-(CH2)m-CH3, wherein n and m = 0 and n + m = 6 to 33. R can be a straight unsaturated C9-36 chain, containing two to six double bonds, with the formula CH3-(CH2)m-(CH=CH)x-(CH2)n-, wherein m, x and n = 0, m + 2x + n = 8 to 35. R can likewise be a straight unsaturated C9-36 chain cantaining one to six double bonds and one triple bond, having the formula CH3-(CH2)-m-C≡C-(CH=CH-CH2)x-, wherein m and x = 0 and m ? 3x = 6 to 33. R may be straight unsaturated chain C9-36 containing one to six double bonds and two to six triple bonds, having the structure CH3-(CH2)m-(C≡C-CH2)y-(CH=CH -CH2)x-(CH2)n-, wherein m, y, x and n = 0 and m + 3y + 3x + n = 8 to 35.

  一种有益于促进皮肤和黏膜组织代谢，从而改善其健康和外观的物质组成。该物质组成具有呋喃(2)-R，其中R是直链C9-36烷基链，具有公式CH3-(CH2)n-(CH2)nCH3，(n = 8至35)。R也可以是一条直链不饱和的C9-36烯基链，具有单个双键，公式为-(CH2)n-CH=CH-(CH2)m-CH3，其中n和m = 0且n + m = 6至33。R可以是一条直链不饱和的C9-36链，含有两到六个双键，公式为CH3-(CH2)m-(CH=CH)x-(CH2)n-，其中m，x和n = 0，m + 2x + n = 8至35。同样，R可以是一条直链不饱和的C9-36链，含有一个到六个双键和一个三键，公式为CH3-(CH2)-m-C≡C-(CH=CH-CH2)x-，其中m和x = 0且m÷3x = 6至33。R也可以是一条直链不饱和的C9-36链，含有一个到六个双键和两到六个三键，具有结构CH3-(CH2)m-(C≡C-CH2)y-(CH=CH-CH2)x-(CH2)n-，其中m，y，x和n = 0，m + 3y + 3x + n = 8至35。
• Lipidic furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic disorders
  申请人：Avoscience, LLC

  公开号：US10085962B2

  公开（公告）日：2018-10-02

  Compounds, methods, and compositions are provided for the treatment of cancer, neurological disorders, and fibrotic disorders. Specifically, the invention includes administering an effective amount of a compound of Formula I, II, or III, or a pharmaceutically acceptable composition, salt, isotopic analog, prodrug, or combination thereof, to a subject suffering from a cancer, neurological disorder, or fibrotic disorder.

  本发明提供了用于治疗癌症、神经系统疾病和纤维化疾病的化合物、方法和组合物。具体来说，本发明包括向患有癌症、神经系统疾病或纤维化疾病的受试者施用有效量的式 I、II 或 III 化合物或其药学上可接受的组合物、盐、同位素类似物、原药或其组合物。