2-Pyridinaldehyd-p-tolylhydrazon | 65373-73-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Pyridinaldehyd-p-tolylhydrazon
• 英文别名: 4-methyl-N-[(E)-pyridin-2-ylmethylideneamino]aniline
• CAS: 65373-73-1
• 化学式: C₁₃H₁₃N₃
• 分子量: 211.266
• InChiKey: FEACXCVIIIOIPX-XNTDXEJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compounds, compositions and methods for treating or preventing viral infections and associated diseases
  申请人：Diana D. Guy

  公开号：US20050288258A1

  公开（公告）日：2005-12-29

  Pyridine derivatives that exhibit antiviral activity are disclosed.

  本发明揭示了具有抗病毒活性的吡啶衍生物。
• Tricyclic compounds protein kinase inhibitors for enhancing the efficacy of anti-neoplastic agents and radiation therapy
  申请人：Benedict Suzanne

  公开号：US20050075499A1

  公开（公告）日：2005-04-07

  Protein kinase, such as CHK-1, inhibiting tricyclic compounds of the following formula (wherein R 2 , R 3 and R 4 are as defined in the specification) pharmaceutical compositions containing effective amounts of said compounds or their salts are useful as a single agent or in combination with an anti-neoplastic agent or therapeutic radiation having an anti-neoplastic effect for treating diseases or conditions such as cancers.

  蛋白激酶，例如CHK-1，抑制以下公式中的三环化合物（其中R2、R3和R4如规范中定义）的药物组合物，包含有效量的该化合物或其盐，可用作单一制剂或与具有抗肿瘤作用的抗肿瘤制剂或治疗性放射线结合，用于治疗癌症等疾病或病况。