5-(1-Adamantyl)-3-[(4-fluorophenyl)sulfanylmethyl]-4-nitroso-1,2-oxazole

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-(1-Adamantyl)-3-[(4-fluorophenyl)sulfanylmethyl]-4-nitroso-1,2-oxazole
• 英文别名: 5-(1-adamantyl)-3-[(4-fluorophenyl)sulfanylmethyl]-4-nitroso-1,2-oxazole
• 化学式: C₂₀H₂₁FN₂O₂S
• 分子量: 372.5
• InChiKey: LLKFJTSJIKBZEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  80.8
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• HETEROCYCLIC COMPOUND HAVING TYPE I 11 BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORY ACTIVITY
  申请人：Ogawa Tomoyuki

  公开号：US20100197662A1

  公开（公告）日：2010-08-05

  Disclosed is a compound useful as a type I 11βhydroxysteroid dehydrogenase inhibitor. A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R 1 is optionally substituted cycloalkyl, optionally substituted cycloalkenyl or the like, One of R 2 and R 3 is a group of the formula: —C(═O)—Y—R 4 , wherein Y is —NR 9 — or the like, R 4 is optionally substituted cycloalkyl or the like, R 9 is hydrogen or optionally substituted alkyl, W is optionally substituted alkylene, The other is a group of the formula: —V—R 5 , wherein V is a bond, —O— or the like, R 6 is hydrogen or optionally substituted alkyl, R 5 is hydrogen, optionally substituted alkyl or the like, X is a bond, —S—, —SO— or the like, U is a bond or optionally substituted alkylene, R 7 is hydrogen or optionally substituted alkyl, Z is —S—, —O— or —NR 8 —, R 8 is hydrogen, optionally substituted alkyl or the like.