(R)-2-(sec-butyl)isoindoline-1,3-dione | 31519-56-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: (R)-2-(sec-butyl)isoindoline-1,3-dione
• 英文别名: N-((R)-sec-butyl)-phthalimide；N-((R)-sec-Butyl)-phthalimid；2-[(1R)-1-Methylpropyl]-1H-isoindole-1,3(2H)-dione；2-[(2R)-butan-2-yl]isoindole-1,3-dione
• CAS: 31519-56-9
• 化学式: C₁₂H₁₃NO₂
• 分子量: 203.241
• InChiKey: ZTXOTHWCDVUQRM-MRVPVSSYSA-N

物化性质

• 沸点：
  302.8±11.0 °C(Predicted)
• 密度：
  1.187±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-((S)-1-[1,3]dithiolan-2-yl-propyl)-phthalimide 在 镍 、 丙酮 作用下， 生成 (R)-2-(sec-butyl)isoindoline-1,3-dione
  参考文献：
  名称：

  Balenovic et al., Journal of the Chemical Society, 1956, p. 3982

  摘要：

  DOI：

文献信息

• Nucleophilic Substitution Reactions of (Alkoxymethylene)dimethylammonium Chloride
  作者：Anthony G. M. Barrett、D. Christopher Braddock、Rachel A. James、Nobuyuki Koike、Panayiotis A. Procopiou

  DOI：10.1021/jo980583j

  日期：1998.9.1

  The use of imidate esters as potential replacements for diethyl azodicarboxylate and triphenylphosphine in the Mitsunobu reaction is described. A series of secondary alcohols were allowed to react with (chloromethylene)dimethylammonium chloride, generated from dimethylformamide (DMF) and oxalyl chloride, to give imidate esters. Reaction of these salts with potassium benzoate or potassium phthalimide

  描述了在Mitsunobu反应中使用亚氨酸酯作为偶氮二羧酸二乙酯和三苯基膦的潜在替代物。使一系列仲醇与由二甲基甲酰胺（DMF）和草酰氯生成的（氯亚甲基）二甲基氯化铵反应，得到亚氨酸酯。这些盐与苯甲酸钾或邻苯二甲酰亚胺钾的反应以极好的收率得到了S（N）2取代的产物，且立体化学清晰易懂。讨论了反应条件的优化，作为通过减少所需亲核试剂的量来增加该方法的原子经济性的手段。
• Amplification of the chiroptical response of UV-transparent amines and alcohols by <i>N</i>-phthalimide derivatization enabling absolute configuration determination through ECD computational analysis
  作者：Daniele Padula、Giuseppe Mazzeo、Ernesto Santoro、Patrizia Scafato、Sandra Belviso、Stefano Superchi

  DOI：10.1039/d0ob00052c

  日期：——

  substrates allowing their reliable absolute configuration determination by computational analysis of ECD spectra. Such a transformation also leads to a significant reduction in the molecular conformational flexibility thus simplifying the conformational analysis required by the computational treatment. The method described herein thus allows the absolute configuration assignment to these challenging substrates

  已证明手性紫外线透明的胺和醇向邻苯二甲酰亚胺的立体选择性转化是增强这些底物的手性响应的简单有效的方法，从而可以通过ECD光谱的计算分析确定其可靠的绝对构型。这种转变还导致分子构象柔性的显着降低，从而简化了计算处理所需的构象分析。因此，本文描述的方法使得对这些具有挑战性的基板的绝对配置分配变得更加容易和可靠。
• Nucleophilic substitution of (alkoxymethylene)dimethylammonium chloride with potassium phthalimide; a convenient procedure for the synthesis of imides with inversion of configuration
  作者：Anthony G. M. Barrett、D. Christopher Braddock、Rachel A. James、Panayiotis A. Procopiou

  DOI：10.1039/a607482k

  日期：——

  Secondary alcohols are converted into their phthalimido derivatives with inversion of configuration via sequential reaction with (chloromethylene)dimethylammonium chloride and potassium phthalimide.

  通过与（氯亚甲基）二甲基氯化铵和邻苯二甲酰亚胺钾的顺序反应，仲醇被转化为具有反转构型的邻苯二甲酰亚胺衍生物。
• Initiators for living carbocationic polymerization
  申请人：Kennedy Joseph

  公开号：US10472457B2

  公开（公告）日：2019-11-12

  In various embodiments, the present invention is directed to new low cost initiator compositions for use with the production of well-defined telechelic PIBs (by LC+P of isobutylene). In various other embodiments, the present invention is directed to methods for using these novel compositions as initiators for isobutylene (IB) and other cationically polymerizable monomers, such as styrene and its derivatives. In still other embodiments, the present invention is directed to structurally new, allyl (and chlorine) telechelic PIBs formed from these new initiator compositions and their derivatives (in particular, hydroxyl telechelic PIB and amine telechelic PIB). In yet other embodiments, the present invention is directed to structurally new polyurethanes, polyureas, and polyurethane ureas made using telechelic PIBs formed from these new initiator compositions.

  在各种实施方案中，本发明涉及用于生产定义明确的远切 PIB 的新型低成本引发剂组合物（通过异丁烯的 LC+P）。在其他各种实施方案中，本发明涉及将这些新型组合物用作异丁烯 (IB) 和其他阳离子可聚合单体（如苯乙烯及其衍生物）的引发剂的方法。在另一些实施方案中，本发明涉及由这些新型引发剂组合物及其衍生物（特别是羟基引发剂 PIB 和胺引发剂 PIB）形成的结构新颖的烯丙基（和氯）引发剂 PIB。在另一些实施例中，本发明涉及使用由这些新引发剂组合物形成的远志 PIB 制成的结构新的聚氨酯、聚氨酯和聚氨酯脲。
• NARGENICIN COMPOUNDS AND USES THEREOF AS ANTIBACTERIAL AGENTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20170305924A1

  公开（公告）日：2017-10-26

  The present invention relates to novel nargenicin related compounds which can inhibit DnaE and have antibacterial, particularly antimycobacterial activity against Mycobacterium tuberculosis. The present invention also relates to method for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis by administering an antimycobacterially effective amount of nargenicin or a nargenicin-related compound and/or their pharmaceutically acceptable salts.