(Z)-5-(fluoro(2,3-dihydronaphthalen-4(1H)-ylidene)methyl)-2,3-dihydro-1,4-dioxene | 1185181-27-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (Z)-5-(fluoro(2,3-dihydronaphthalen-4(1H)-ylidene)methyl)-2,3-dihydro-1,4-dioxene
• 英文别名: 5-[(Z)-3,4-dihydro-2H-naphthalen-1-ylidene(fluoro)methyl]-2,3-dihydro-1,4-dioxine
• CAS: 1185181-27-4
• 化学式: C₁₅H₁₅FO₂
• 分子量: 246.281
• InChiKey: JYKZIHSKZKWRPZ-SQFISAMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,4-二氧杂-2-己烯 、 1-(bromofluoromethylene)-1,2,3,4-tetrahydronaphthalene 在 正丁基锂 、 zinc(II) chloride 、 palladium diacetate 、 三苯基膦 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.0h， 生成 (E)-5-(fluoro(2,3-dihydronaphthalen-4(1H)-ylidene)methyl)-2,3-dihydro-1,4-dioxene 、 (Z)-5-(fluoro(2,3-dihydronaphthalen-4(1H)-ylidene)methyl)-2,3-dihydro-1,4-dioxene
  参考文献：
  名称：

  Synthesis of tetrasubstituted α-fluoroenones

  摘要：

  We reported the synthesis of tetrasubstituted alpha-fluoroenones from tetrasubstituted gem-bromo-fluoroolefins in good yields. These compounds are scarcely studied in the literature, due to difficulty of synthesis, whereas they could serve as intermediates in the synthesis of biological relevant molecules and could also be envisioned to design new constrained peptidomimetics. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.05.065

文献信息

• Synthesis of tetrasubstituted α-fluoroenones
  作者：Guillaume Dutheuil、Samuel Couve-Bonnaire、Xavier Pannecoucke

  DOI：10.1016/j.tet.2009.05.065

  日期：2009.8

  We reported the synthesis of tetrasubstituted alpha-fluoroenones from tetrasubstituted gem-bromo-fluoroolefins in good yields. These compounds are scarcely studied in the literature, due to difficulty of synthesis, whereas they could serve as intermediates in the synthesis of biological relevant molecules and could also be envisioned to design new constrained peptidomimetics. (C) 2009 Elsevier Ltd. All rights reserved.