5,7-Dihydroxy-6-methyl-8-methoxy-3-(4'-hydroxybenzyl)chroman-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 高异黄酮
• 英文名称: 5,7-Dihydroxy-6-methyl-8-methoxy-3-(4'-hydroxybenzyl)chroman-4-one
• 英文别名: 5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-8-methoxy-6-methyl-2,3-dihydrochromen-4-one
• 化学式: C₁₈H₁₈O₆
• 分子量: 330.3
• InChiKey: MDFVUCLEMCGDDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Edible composition
  申请人：Conopco, Inc.

  公开号：US10806744B2

  公开（公告）日：2020-10-20

  Foods or meals high in available carbohydrate such as sucrose or starch increase postprandial blood glucose concentrations. According to Node et al. (Cardiovascular diabetology, 8, 23 (2009)), repeated high post-prandial plasma glucose “spikes” are associated with an increased risk of developing type II diabetes. Unregulated glycemic excursions are undesirable, and any reduction or “blunting” of the post-prandial glucose concentration in blood is potentially beneficial. This invention relates to an edible composition for delay of intestinal glucose uptake through synergistic inhibition of both active sodium glucose co-transporter 1 (SGLT1) and passive glucose transporter 2 (GLUT2) leading to flattening or blunting of the post-prandial glucose peak. Thus in a first aspect of the invention, an edible composition provided in the form of a single serving of one or more unit dosages comprising a combination of 2 to 200 mg of at least one homoisoflavonoid and 20 to 2000 mg of at least one flavonoid monoglucoside, and salts thereof.

  蔗糖或淀粉等碳水化合物含量高的食物或膳食会增加餐后血糖浓度。根据 Node 等人（《心血管糖尿病学》，8, 23 (2009)）的研究，反复出现餐后血浆葡萄糖 "飙升 "与罹患 II 型糖尿病的风险增加有关。不受调节的血糖偏移是不可取的，任何降低或 "钝化 "餐后血糖浓度的做法都可能是有益的。本发明涉及一种可食用组合物，通过协同抑制活性钠葡萄糖协同转运体 1（SGLT1）和被动葡萄糖转运体 2（GLUT2），延缓肠道葡萄糖摄取，从而使餐后葡萄糖峰值变平或变钝。因此，在本发明的第一方面，一种以一份或多份单位剂量形式提供的可食用组合物，包含 2 至 200 毫克至少一种同异黄酮和 20 至 2000 毫克至少一种黄酮单葡糖苷及其盐的组合。
• EDIBLE COMPOSITION
  申请人：Unilever PLC

  公开号：EP3344070B1

  公开（公告）日：2019-12-18
• [EN] COMPOSITIONS OF POLYGONUM ODORATUM FOR PREVENTION AND TREATMENT OF DISEASE<br/>[FR] COMPOSITIONS DE POLYGONUM ODORATUM POUR LA PREVENTION ET LE TRAITEMENT D'AFFECTIONS
  申请人：UNIV RUTGERS

  公开号：WO2001056580A1

  公开（公告）日：2001-08-09

  Compositions and methods for prevention and treatment of cancer are provided which comprise extracts of Polygonum odoratum or compounds isolated therefrom.
• [EN] EDIBLE COMPOSITION<br/>[FR] COMPOSITION COMESTIBLE
  申请人：UNILEVER PLC

  公开号：WO2017036926A1

  公开（公告）日：2017-03-09

  Foods or meals high in available carbohydrate such as sucrose or starch increase postprandial blood glucose concentrations. According to Node et al. (Cardiovascular diabetology, 8, 23 (2009)), repeated high post-prandial plasma glucose "spikes" are associated with an increased risk of developing type II diabetes. Unregulated glycemic excursions are undesirable, and any reduction or "blunting" of the post-prandial glucose concentration in blood is potentially beneficial. This invention relates to an edible composition for delay of intestinal glucose uptake through synergistic inhibition of both active sodium glucose co-transporter 1 (SGLT1 ) and passive glucose transporter 2 (GLUT2) leading to flattening or blunting of the post-prandial glucose peak. Thus in a first aspect of the invention, an edible composition provided in the form of a single serving of one or more unit dosages comprising a combination of 2 to 200 mg of at least one homoisoflavonoid and 20 to 2000 mg of at least one flavonoid monoglucoside, and salts thereof.