1'-Hydroxy-2'-ketoisorhodoptilometrin

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1'-Hydroxy-2'-ketoisorhodoptilometrin
• 英文别名: 1,3,8-trihydroxy-6-(1-hydroxy-2-oxopropyl)anthracene-9,10-dione
• 化学式: C₁₇H₁₂O₇
• 分子量: 328.27
• InChiKey: MOMXJBBUVWRYDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• COMPOSITIONS AND METHODS THAT INHIBIT QUORUM SENSING
  申请人：The Office of Innovation Commercialization

  公开号：US20180280321A1

  公开（公告）日：2018-10-04

  This disclosure describes pharmaceutical compositions and methods that involve the use of a polyhydroxyanthraquinone to inhibit quorum sensing in a microbe. In some embodiments, the polyhydroxyanthraquinone may be effective to antagonize AgrA function in a microbe. In other embodiments, the polyhydroxyanthraquinone may be effective for prophylactic and/or therapeutic treatment of a skin and soft tissue infection (SSTI) of a subject by a microbe. In still other embodiments, the polyhydroxyanthraquinone may be effective to reduce, limit progression, ameliorate, or resolve, to any extent, a symptom or clinical sign of infection by a microbe.