2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]thiophene-3-carbaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,5-Dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]thiophene-3-carbaldehyde
• 英文别名: 2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]thiophene-3-carbaldehyde
• 化学式: C₁₅H₁₃F₃OS
• 分子量: 298.3
• InChiKey: NQBVPQQMANJLHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS
  申请人：Blouin Marc

  公开号：US20090247596A1

  公开（公告）日：2009-10-01

  The invention is directed to thiophenecarboxamide derivatives of formulae I and II as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, cancer and glaucoma. Pharmaceutical compositions and methods of use are also included. (Formulas I and II).

  本发明涉及公式I和II的噻吩羧酰胺衍生物，作为EP4受体配体、拮抗剂或激动剂，用于治疗EP4介导的疾病或症状，如急性和慢性疼痛、骨关节炎、类风湿性关节炎、癌症和青光眼。还包括药物组合物和使用方法。(公式I和II)
• PROCESS FOR MAKING THIOPHENE CARBOXAMIDE DERIVATIVES
  申请人：DAVIES Ian

  公开号：US20100204487A1

  公开（公告）日：2010-08-12

  The invention encompasses a process for making a thiophene carboxamide derivative, which is an EP4 antagonist useful for treating pain and inflammation.