2-Methylidene-6-azabicyclo[3.2.0]heptan-7-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 2-Methylidene-6-azabicyclo[3.2.0]heptan-7-one
• 英文别名: 2-methylidene-6-azabicyclo[3.2.0]heptan-7-one
• 化学式: C₇H₉NO
• 分子量: 123.15
• InChiKey: NZSDSZYLRUTTCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Preparation Of Synthetic Nucleosides via Pi-Allyl Transition Metal Complex Formation
  申请人：Liotta Dennis C.

  公开号：US20100204463A1

  公开（公告）日：2010-08-12

  This invention provides highly regioselective and stereoselective processes for preparing synthetic nucleosides. A process for the preparation of synthetic nucleosides is provided that comprises a) preparing a bicycloamide derivative, b) reacting the bicycloamide derivative with a nucleic acid base or heterocyclic base or salt thereof in the presence of a transition metal catalyst to form a cyclopentenecarboxamide, and c) cleaving a carboxamide group from the cyclopentenecarboxamide to form the synthetic nucleoside. The processes according to the invention can be used for the synthesis of a variety of anti-viral agents, including Abacavir, Carbovir, and Entecavir, as well as derivatives thereof.