8-(3-Oxa-tricyclo[3.2.1.02,4]oct-6-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione | 166181-76-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 8-(3-Oxa-tricyclo[3.2.1.02,4]oct-6-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
• 英文别名: 8-(3-oxatricyclo[3.2.1.02,4]octan-6-yl)-1,3-dipropyl-7H-purine-2,6-dione
• CAS: 166181-76-6
• 化学式: C₁₈H₂₄N₄O₃
• 分子量: 344.414
• InChiKey: OQCJPFYWFGUHIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  81.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  8-Bicyclo[2.2.1]hept-5-en-2-yl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 40.0h， 生成 8-(3-Oxa-tricyclo[3.2.1.02,4]oct-6-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
  参考文献：
  名称：

  Belardinelli; Shryock; Zhang, Journal of Pharmacology and Experimental Therapeutics, 1995, vol. 275, # 3, p. 1167 - 1176

  摘要：

  DOI：

文献信息

• Methods of treating pulmonary disease
  申请人：——

  公开号：US20040259889A1

  公开（公告）日：2004-12-23

  Methods useful for reducing pulmonary vasoconstriction or improving pulmonary hemodynamics in a patient are disclosed. More particularly, this invention relates to administering A 1 adenosine receptor antagonists to reduce pulmonary vasoconstriction and improve pulmonary hemodynamics.

  本发明涉及使用A1腺苷受体拮抗剂来减少肺血管收缩并改善肺血液动力学。
• Active agent delivery systems and methods for protecting and administering active agents
  申请人：New River Pharmaceuticals Inc.

  公开号：US20040063628A1

  公开（公告）日：2004-04-01

  The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions.

  本发明涉及活性物质输送系统，更具体地涉及包含氨基酸，作为单个氨基酸或肽的组成部分，与活性物质共价连接的组合物和用于给予共轭活性物质组合物的方法。
• ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS
  申请人：Mickle Travis

  公开号：US20090253792A1

  公开（公告）日：2009-10-08

  The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions.

  本发明涉及活性剂递送系统，更具体地涉及包含氨基酸（作为单个氨基酸或肽）与活性剂共价连接的组合物以及给予共轭活性剂组合物的方法。
• ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS
  申请人：Mickle Travis

  公开号：US20090306228A1

  公开（公告）日：2009-12-10

  The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions.

  本发明涉及活性剂递送系统，更具体地涉及包含氨基酸，作为单个氨基酸或肽，与活性剂共价结合的组合物以及用于给予共轭活性剂组合物的方法。
• Active agent delivery sytems and methods for protecting and administering active agents
  申请人：Shire LLC

  公开号：EP2266590A2

  公开（公告）日：2010-12-29

  The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions.

  本发明涉及活性剂给药系统，更具体地说，涉及由与活性剂共价连接的氨基酸（作为单个氨基酸或肽）组成的组合物以及给药共轭活性剂组合物的方法。