vanillin-4-sulphate | 744984-09-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: vanillin-4-sulphate
• 英文别名: 3-methoxy-4-sulfooxy-benzaldehyde；vanillin-sulfuric acid；vanilline-sulfuric acid；vanillin-sulphuric acid；4-Formyl-2-methoxyphenyl hydrogen sulfate；(4-formyl-2-methoxyphenyl) hydrogen sulfate
• CAS: 744984-09-6
• 化学式: C₈H₈O₆S
• 分子量: 232.214
• InChiKey: OUIKMDRGUNIXSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  98.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  香草醛 在 吡啶 、 氯磺酸 、 氯仿 作用下， 生成 vanillin-4-sulphate
  参考文献：
  名称：

  Neuberg; Wagner, Biochemische Zeitschrift, 1925, vol. 161, p. 501

  摘要：

  DOI：

文献信息

• Modulators (inhibitors/ activators) of histone acetyltransferases
  申请人：Kundu Kumar Tapas

  公开号：US20060167107A1

  公开（公告）日：2006-07-27

  Disclosed are compounds of the formulae: and method of using the compounds to treat cancer, AIDS, HIV infection, and asthma.

  揭示了以下式的化合物： 以及使用这些化合物治疗癌症、艾滋病、HIV感染和哮喘的方法。
• Indolyl-Substituted Pyrazino-Quinolines and Their Use for the Treatment of Cancer
  申请人：Persson Jenny

  公开号：US20120157461A1

  公开（公告）日：2012-06-21

  There is provided compounds of formula I, wherein the wedged bonds, R 1 , R 2 , R 3 , R 4 , R 5 , R 5a , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , X and Y have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of cancer and conditions affected by inhibition of angiogenesis.

  提供的是公式I的化合物，其中斜线键、R1、R2、R3、R4、R5、R5a、R6、R7、R8、R9、R10、R11、R12、R13、R14、X和Y的含义如描述中所述，以及药用可接受的盐，这些化合物在治疗癌症和受血管生成抑制影响的状态中有用。
• New spiroepoxide tetrahydrobenzo-triazoles and -imidazoles and their use as MetAP-II inhibitors
  申请人：Deutsches Krebsforschungszentrum

  公开号：EP2711367A1

  公开（公告）日：2014-03-26

  The present invention relates to new spiroepoxide tetrahydrobenzo-triazole and - imidazole compounds, a method for their production and their use as MetAP-II inhibitors, which are particularly useful as inhibitors of angiogenesis. The compounds are characterized by formula (I) X=CorN R1 = OC(O)R2 where R2 is alkyl, cycloalkyl, aryl, heteroaryl, or cinnamyl or R1 = OC(O)NHR3 where R3 is alkyl, cycloalkyl, aryl, or heteroaryl or R1 = NHC(O)OR4 where R4 is alkyl or R1 = OH, NH2 R5 = alkyl, cycloalkyl, CH2R6 where R6 is aryl or heteroaryl

  本发明涉及新的螺环氧四氢苯并三唑和咪唑化合物，它们的制备方法以及它们作为MetAP-II抑制剂的用途，特别是作为抑制血管生成的抑制剂。这些化合物的特征是公式（I）X=CorNR1=OC（O）R2，其中R2是烷基，环烷基，芳基，杂芳基或肉桂基，或R1=OC（O）NHR3，其中R3是烷基，环烷基，芳基或杂芳基，或R1=NHC（O）OR4，其中R4是烷基，或R1=OH，NH2，R5=烷基，环烷基，CH2，R6是芳基或杂芳基。
• Cytotoxic agents containing novel potent taxanes and their therapeutic use
  申请人：IMMUNOGEN INC.

  公开号：US20040024049A1

  公开（公告）日：2004-02-05

  Included within the scope of the present invention are potent taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well.

  本发明的范围包括含有连接基的有效紫杉醇类化合物。还包括一种细胞毒性剂，该细胞毒性剂包括一个或多个紫杉醇类化合物与一个细胞结合剂连接。还包括一种治疗组合物，用于诱导选定细胞群体的细胞死亡，包括：（A）通过连接基与细胞结合剂共价键合的一个或多个紫杉醇类化合物的细胞毒性量，以及（B）一种药学上可接受的载体、稀释剂或赋形剂。本发明还包括一种诱导选定细胞群体的细胞死亡的方法，包括将含有目标细胞或组织的靶细胞与连接有一个或多个紫杉醇类化合物的细胞结合剂的细胞毒性剂的有效量接触。
• Epothilones C, D, E and F, preparation and compositions
  申请人：Hoefle Gerhard

  公开号：US20060264482A1

  公开（公告）日：2006-11-23

  The present invention relates to epothilones C, D, E and F, their preparation and their use for the production of therapeutic compositions and compositions for plant production.

  本发明涉及依托泊瑞松C、D、E和F，它们的制备以及它们用于生产治疗组合物和植物生产组合物的用途。