5-[5'-fluoro-2'-(2,2,3,3,3-pentafluoropropyloxy)biphenyl-3-yl]-2H-1,2,4-triazole-3-carboxamide | 852317-38-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[5'-fluoro-2'-(2,2,3,3,3-pentafluoropropyloxy)biphenyl-3-yl]-2H-1,2,4-triazole-3-carboxamide
• 英文别名: 3-[5'-fluoro-2'-(2,2,3,3,3-pentafluoropropoxy)biphenyl-3-yl]-1H-1,2,4-triazole-5-carboxamide；3-[3-[5-fluoro-2-(2,2,3,3,3-pentafluoropropoxy)phenyl]phenyl]-1H-1,2,4-triazole-5-carboxamide
• CAS: 852317-38-5
• 化学式: C₁₈H₁₂F₆N₄O₂
• 分子量: 430.309
• InChiKey: OWSLGPREZQMVQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  93.9
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Substituted triazoles as sodium channel blockers
  申请人：Park K. Min

  公开号：US20060020006A1

  公开（公告）日：2006-01-26

  Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

  公式I、II或III所代表的取代三唑化合物，或其药学上可接受的盐。制药组合物包括有效量的本化合物，可以单独使用，也可以与一个或多个其他治疗活性化合物组合使用，并与药学上可接受的载体一起使用。治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛、慢性疼痛、内脏疼痛、炎性疼痛、神经病性疼痛、偏头痛、头痛疼痛、癫痫、肠易激综合征、糖尿病神经病、多发性硬化症、躁郁症和双相情感障碍等，包括单独使用或与一个或多个其他治疗活性化合物组合使用，以及药学上可接受的载体。一种局部麻醉的方法包括给予本发明化合物的有效量，可以单独使用，也可以与一个或多个其他治疗活性化合物组合使用，并与药学上可接受的载体一起使用。
• Substituted Triazoles as Sodium Channel Blockers
  申请人：Park Min K.

  公开号：US20090074890A1

  公开（公告）日：2009-03-19

  Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier (I), (II), (III).

  公式I、II或III所代表的取代三唑化合物，或其药学上可接受的盐。药物组合物包括有效量的本化合物，单独使用或与一个或多个其他治疗活性化合物联合使用，并加入药学上可接受的载体。治疗与钠通道活性相关或由其引起的疾病的方法，包括急性疼痛、慢性疼痛、内脏疼痛、炎性疼痛、神经痛、偏头痛、头痛、偏头痛头痛、癫痫、肠易激综合征、糖尿病性神经病、多发性硬化症、躁郁症等，包括单独使用或与一个或多个其他治疗活性化合物联合使用的有效量的本化合物的给药。一种局部麻醉的给药方法包括给予本发明化合物的有效量，单独使用或与一个或多个其他治疗活性化合物联合使用，并加入药学上可接受的载体(I)、(II)、(III)。
• SUBSTITUTED TRIAZOLES AS SODIUM CHANNEL BLOCKERS
  申请人：Merck & Co., Inc.

  公开号：EP1694654A2

  公开（公告）日：2006-08-30
• US7459475B2
  申请人：——

  公开号：US7459475B2

  公开（公告）日：2008-12-02
• [EN] SUBSTITUTED TRIAZOLES AS SODIUM CHANNEL BLOCKERS<br/>[FR] TRIAZOLES SUBSTITUES UTILISES EN TANT QUE BLOQUEURS DU CANAL SODIQUE
  申请人：MERCK & CO INC

  公开号：WO2005047270A2

  公开（公告）日：2005-05-26

  Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier (I), (II), (III).