2,4,6-Trimethyl-7-oxocyclohepta-1,3,5-trien-1-YL 4-chlorobenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4,6-Trimethyl-7-oxocyclohepta-1,3,5-trien-1-YL 4-chlorobenzoate
• 英文别名: (2,4,6-trimethyl-7-oxocyclohepta-1,3,5-trien-1-yl) 4-chlorobenzoate
• 化学式: C₁₇H₁₅ClO₃
• 分子量: 302.7
• InChiKey: PDPAMMYSJLPRNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• HBV RNAse H purification and enzyme inhibitors
  申请人：Saint Louis University

  公开号：US10329542B2

  公开（公告）日：2019-06-25

  Provided herein are methods for the obtention of an active HBV RNaseH preparation and its use in screening methods to identify potential inhibitors of the enzyme for possible use as therapeutic agents. Also provided are methods of treatment using agents identified according to the screen.

  本文提供了获得活性 HBV RNaseH 制剂的方法及其在筛选方法中的应用，以确定可能用作治疗剂的潜在酶抑制剂。还提供了使用根据筛选确定的制剂进行治疗的方法。
• Inhibitors of HSV nucleotidyl transferases and uses therefor
  申请人：Saint Louis University

  公开号：US10463664B2

  公开（公告）日：2019-11-05

  The present invention involves identification of inhibitors of herpesvirus nucleic acid metabolism. Also provided are methods of treatment using agents identified.

  本发明涉及疱疹病毒核酸代谢抑制剂的鉴定。还提供了使用鉴定出的制剂进行治疗的方法。
• INHIBITORS OF HSV NUCLEOTIDYL TRANSFERASES AND USES THEREFOR
  申请人：SAINT LOUIS UNIVERSITY

  公开号：US20160296521A1

  公开（公告）日：2016-10-13

  The present invention involves identification of inhibitors of herpesvirus nucleic acid metabolism. Also provided are methods of treatment using agents identified.
• [EN] INHIBITORS OF HSV NUCLEOTIDYL TRANSFERASES AND USES THEREFOR<br/>[FR] INHIBITEURS DE NUCLÉOTIDYL-TRANSFÉRASES DU VHS ET LEURS UTILISATIONS
  申请人：UNIV SAINT LOUIS

  公开号：WO2015077774A1

  公开（公告）日：2015-05-28

  The present invention involves identification of inhibitors of herpesvirus nucleic acid metabolism. Also provided are methods of treatment using agents identified.