N-methyl-2-phenyl-N-[7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-yl]acetamide | 90244-68-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-2-phenyl-N-[7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-yl]acetamide
• 英文别名: N-methyl-2-phenyl-N-(7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl)acetamide
• CAS: 90244-68-1
• 化学式: C₂₂H₃₂N₂O₂
• 分子量: 356.5
• InChiKey: PGZRDDYTKFZSFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] PYRIDOMORPHINANS AND USE THEREOF<br/>[FR] PYRIDOMORPHINANES ET UTILISATION
  申请人：SOUTHERN RES INST

  公开号：WO2001012196A1

  公开（公告）日：2001-02-22

  Compounds represented by formula (I) wherein each of Y, X and R individually is H, OH, alkyl, alkoxy, aryl, halo, CF3 and NO2, provided that at least one of Y, X and R is other than H; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain, as immunomodulators and for treating drug abuse.

  公式（I）所代表的化合物中，Y、X和R中的每一个单独可以是H、OH、烷基、烷氧基、芳香基、卤素、CF3和NO2，但至少一个Y、X和R不是H；并提供其药物可接受的盐。上述公式的化合物可用作镇痛剂治疗疼痛、免疫调节剂以及治疗药物滥用。
• Oligomer-Opioid Agonist Conjugates
  申请人：Riggs-Sauthier Jennifer

  公开号：US20100048602A1

  公开（公告）日：2010-02-25

  The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

  该发明提供了通过共价连接水溶性寡聚体进行化学修饰的化合物。该发明的化合物在通过任何一种给药途径给予时，表现出与未连接水溶性寡聚体的化合物不同的特性。
• OLIGOMER-OPIOID AGONIST CONJUGATES
  申请人：NEKTAR THERAPEUTICS

  公开号：US20150112069A1

  公开（公告）日：2015-04-23

  The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

  该发明提供了通过共价连接水溶性寡聚体进行化学修饰的化合物。该发明的化合物在通过多种给药途径给予时，表现出与未连接水溶性寡聚体的化合物不同的特性。
• EP1200089A4
  申请人：——

  公开号：EP1200089A4

  公开（公告）日：2002-11-13
• PYRIDOMORPHINANS AND USE THEREOF
  申请人：Southern Research Institute

  公开号：EP1200089A1

  公开（公告）日：2002-05-02