2-ethyl-3,4-dimethyl-thiophene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-ethyl-3,4-dimethyl-thiophene
• 英文别名: 2-Aethyl-3,4-dimethyl-thiophen；2-Ethyl-3,4-dimethylthiophene
• 化学式: C₈H₁₂S
• 分子量: 140.249
• InChiKey: PHAZZTDHDXIVAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-ethyl-3,4-dimethyl-thiophene 、 mercury(II) diacetate 生成 5-ethyl-3,4-dimethyl-[2]thienylmercury (1+); acetate
  参考文献：
  名称：

  中东原油煤油沸腾范围内的硫化合物

  摘要：

  DOI：

  10.1021/ie50542a027

文献信息

• GPR40 AGONISTS
  申请人：Kuo Gee-Hong

  公开号：US20080176912A1

  公开（公告）日：2008-07-24

  The invention is directed to compounds of Formula (I) useful as GPR40 agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, insulin resistance, hyperglycemia, obesity, diabetes such as NIDDM, and other disorders related to lipid metabolism, energy homeostasis, and complications thereof, using compounds of the invention are also described.

  这项发明涉及一种化合物，其化学式为（I），可用作GPR40激动剂。还描述了使用该发明的化合物治疗一个或多个病症的药物组合物和方法，包括但不限于胰岛素抵抗、高血糖、肥胖、糖尿病（如NIDDM）以及与脂质代谢、能量稳态和相关并发症有关的其他疾病。
• HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS
  申请人：NUVATION BIO INC.

  公开号：US20200231570A1

  公开（公告）日：2020-07-23

  Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

  提供了氨基吡嗪化合物作为腺苷受体的调节剂。这些化合物可能作为治疗经由G蛋白偶联受体信号通路介导的疾病的治疗剂，并且可能在肿瘤学中发挥特定作用。
• SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT COMPRISING THE SAME
  申请人：Otomo Akira

  公开号：US20120172599A1

  公开（公告）日：2012-07-05

  Problem to Be Solved: to provide a chromophore having a far superior nonlinear optical activity to conventional chromophores and to provide a nonlinear optical element comprising said chromophore. Solution: a chromophore comprising a donor structure D, a π-conjugated bridge structure B, and an acceptor structure A, the donor structure D comprising an aryl group substituted with a substituted oxy group; and a nonlinear optical element comprising said chromophore.

  问题要解决的是：提供一种具有比传统色团更优越的非线性光学活性的色团，并提供包括该色团的非线性光学元件。解决方案是：一种包括给体结构D、π-共轭桥结构B和受体结构A的色团，其中给体结构D包括一个被取代氧基取代的芳基；以及包括该色团的非线性光学元件。
• [EN] SUBSTITUTED THIENO[2,3-C]PYRIDAZINE-6-CARBOXAMIDE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4<br/>[FR] ANALOGUES DE THIÉNO[2,3-C]PYRIDAZINE-6-CARBOXAMIDE SUBSTITUÉS UTILISÉS EN TANT QUE MODULATEURS ALLOSTÉRIQUES POSITIFS DU RÉCEPTEUR MUSCARINIQUE DE L'ACÉTYLCHOLINE M4
  申请人：UNIV VANDERBILT

  公开号：WO2015027214A1

  公开（公告）日：2015-02-26

  In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6- carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在某个方面，该发明涉及替代的5-氨基噻吩[2,3-c]吡啶嗪-6-羧酰胺类似物，其衍生物以及相关化合物，这些化合物可用作肌胆碱受体M4的正向变构调节剂（mAChR M4）；制备这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗与肌胆碱受体功能障碍相关的神经和精神疾病的方法。本摘要旨在作为在特定领域进行搜索的扫描工具，并不旨在限制本发明。
• Process for desulfurizing catalytically cracked gasoline
  申请人：MITSUBISHI OIL CO., LTD.

  公开号：EP0725126A1

  公开（公告）日：1996-08-07

  An efficient process for desulfurizing catalytically cracked gasoline, in which a reduction in olefin content is controlled to thereby minimize a reduction in octane number. A catalytically cracked gasoline is separated into a plurality of fractions including one or both of a fraction rich in sulfur compounds that are hard to desulfurize and a fraction rich in sulfur compounds that are easy to desulfurize. One or both of the fractions are subjected to hydrodesulfurization. The resulting fractions are then mixed with the remaining fractions.

  一种高效的催化裂化汽油脱硫工艺，可控制烯烃含量的减少，从而最大限度地降低辛烷值。将催化裂化汽油分离成多个馏分，其中包括富含硫化合物的难脱硫馏分和富含硫化合物的易脱硫馏分中的一种或两种。对其中的一种或两种馏分进行加氢脱硫。然后将得到的馏分与其余馏分混合。