3-[4-(Dihydroxyamino)-3-(trifluoromethyl)phenyl]-5,5-dimethylimidazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-[4-(Dihydroxyamino)-3-(trifluoromethyl)phenyl]-5,5-dimethylimidazolidine-2,4-dione
• 英文别名: 3-[4-(dihydroxyamino)-3-(trifluoromethyl)phenyl]-5,5-dimethylimidazolidine-2,4-dione
• 化学式: C₁₂H₁₂F₃N₃O₄
• 分子量: 319.24
• InChiKey: PHYQBTYHYRHLPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  93.1
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Non-Androgen Dependent Roles for Androgen Receptor and Non-Androgen Related Inhibitors of Androgen Receptor
  申请人：Chang Chawnshang

  公开号：US20080050387A1

  公开（公告）日：2008-02-28

  Disclosed are compositions and methods for modulating AR activity, such as non-androgen dependent AR activity. Also disclosed are compositions and methods for diagnosing beast cancer and for inhibiting breast cancer growth. In addition, disclosed are methods for identifying molecules that inhibit AR in non-androgen dependent ways.