2,3,3-trimethyl-4H-isoquinolin-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2,3,3-trimethyl-4H-isoquinolin-1-one
• 化学式: C₁₂H₁₅NO
• 分子量: 189.257
• InChiKey: PIUOLQWKPUKJSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-甲基苯甲酰胺 、 二叔丁基过氧化物 在 palladium diacetate 、 三氟乙酸 作用下， 以 环己烷 为溶剂， 反应 0.5h， 以10%的产率得到2,3,3-trimethyl-4H-isoquinolin-1-one
  参考文献：
  名称：

  Modular synthesis of dihydro-isoquinolines: palladium-catalyzed sequential C(sp²)–H and C(sp³)–H bond activation

  摘要：

  通过Pd催化的双C-H键活化/环化，实现二氢异喹啉的高效合成，具有短反应时间、高原子经济性和形成立体位阻较小的三级C-N键。

  DOI：

  10.1039/c5sc01482d

文献信息

• POLYMER HAVING A STRUCTURE OF POLYAMIDE, POLYAMIDE-IMIDE, OR POLYIMIDE, PHOTOSENSITIVE RESIN COMPOSITION, PATTERNING PROCESS, PHOTOSENSITIVE DRY FILM, AND PROTECTIVE FILM FOR ELECTRIC AND ELECTRONIC PARTS
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20200041903A1

  公开（公告）日：2020-02-06

  The present invention is a polymer having a polyamide structural unit, a polyamide-imide structural unit, or a polyimide structural unit, selected from a polyamide, a polyamide-imide, a polyimide, a polyimide precursor, a polybenzoxazole, and a polybenzoxazole precursor, including a reaction product of a diamine containing at least one of a diamine shown by the following general formula (1) and a diamine shown by the following general formula (2), together with at least one of a tetracarboxylic dianhydride shown by the following general formula (3) as well as a dicarboxylic acid and a dicarboxylic halide shown by the following general formula (4). This provides a polymer which is soluble in a safe organic solvent used widely, and is usable as a base resin of a positive photosensitive resin composition that is soluble in an aqueous alkaline solution and capable of forming a fine pattern to give higher resolution.
• Modular synthesis of dihydro-isoquinolines: palladium-catalyzed sequential C(sp²)–H and C(sp³)–H bond activation
  作者：Weidong Liu、Qingzhen Yu、Le'an Hu、Zenghua Chen、Jianhui Huang

  DOI：10.1039/c5sc01482d

  日期：——

  An efficient synthesis of dihydro-isoquinolines via a Pd–catalyzed double C–H bond activation/annulation featuring a short reaction time, high atom economy and the formation of a sterically less favoured tertiary C–N bond.

  通过Pd催化的双C-H键活化/环化，实现二氢异喹啉的高效合成，具有短反应时间、高原子经济性和形成立体位阻较小的三级C-N键。