p-hydroxyphenyl-2,3-dihydroxypropylether | 22402-45-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: p-hydroxyphenyl-2,3-dihydroxypropylether
• 英文别名: rac-3-(4-hydroxyphenoxy)propane-1,2-diol；3-(4'-Hydroxy)-phenoxypropandiol-(1,2)；3-(p-hydroxy)-phenoxy-propandiol-(1,2)；3-(4-hydroxy-phenoxy)-propane-1,2-diol；3-(4-Hydroxy-phenoxy)-propan-1,2-diol；4-(2,3-dihydroxypropoxy)phenol；3-(4-hydroxyphenoxy)propane-1,2-diol
• CAS: 22402-45-5
• 化学式: C₉H₁₂O₄
• 分子量: 184.192
• InChiKey: QAKJEUIMEVJFTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2909499000

反应信息

• 作为反应物：
  描述：

  p-hydroxyphenyl-2,3-dihydroxypropylether 在 水 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 31.5h， 生成 (+)-1-(4-Hydroxyphenoxy)-3-isopropyl-amino-2-propanol
  参考文献：
  名称：

  Effective synthesis of non-racemic prenalterol based on spontaneous resolution of 3-(4-hydroxyphenoxy)propane-1,2-diol

  摘要：

  Spontaneous resolution of rac-3-(4-hydroxyphenoxy)propane-1,2-diol has been successfully used in the synthesis of both enantiomers of chiral drug prenalterol.

  DOI：

  10.1016/j.mencom.2019.03.028
• 作为产物：
  描述：

  3-(4-甲氧基苯氧基)-1,2-丙二醇 在 氢溴酸 作用下， 以 水 为溶剂， 生成 p-hydroxyphenyl-2,3-dihydroxypropylether
  参考文献：
  名称：

  Effective synthesis of non-racemic prenalterol based on spontaneous resolution of 3-(4-hydroxyphenoxy)propane-1,2-diol

  摘要：

  Spontaneous resolution of rac-3-(4-hydroxyphenoxy)propane-1,2-diol has been successfully used in the synthesis of both enantiomers of chiral drug prenalterol.

  DOI：

  10.1016/j.mencom.2019.03.028

文献信息

• NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE
  申请人：Okano Akihiro

  公开号：US20120157459A1

  公开（公告）日：2012-06-21

  [Problem] To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogue and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases. [Means of solving the problem] A compound of Formula (I): (where n is 0 to 2; p is 0 to 4; j is 0 to 3; k is 0 to 2; a ring A is an aryl group which is optionally substituted with L or a heterocyclic group which is optionally substituted with L; a ring B is a benzene ring, a pyridine ring, or a pyrimidine ring; X is O, S, —NR 7 —; and R 1 to R 7 are specific groups), a salt of the compound, or a solvate of the salt or the compound.

  提供一个以新型化合物作为活性成分的GPR40激活剂，该化合物具有GPR40激动剂作用，该化合物的盐，该盐或化合物的溶剂合物，或者类似物，尤其是胰岛素分泌促进剂以及对糖尿病、肥胖症或其他疾病的预防及/或治疗剂。[解决该问题的方法] 公式(I)的化合物：（其中n为0至2；p为0至4；j为0至3；k为0至2；环A是一个芳基团，可选择性被L取代或是一个杂环团，可选择性被L取代；环B是一个苯环、一个吡啶环或一个嘧啶环；X是O，S，—NR7—；R1至R7是特定基团），该化合物的盐，或该盐或化合物的溶剂合物。
• [EN] PROCESS FOR PREPARING HYDROXYTYROSOL<br/>[FR] PROCÉDÉ DE PRÉPARATION DE L'HYDROXYTYROSOL
  申请人：LONZA AG

  公开号：WO2012003625A1

  公开（公告）日：2012-01-12

  A process for preparing hydroxytyrosol from eugenol is disclosed. The eugenol can be converted to 4-(2-hydroxyethyl)-2-methoxyphenol, which is subsequently converted to hydroxytyrosol. The eugenol can also be initially demethylated, and the reaction product is subsequently converted to hydroxytyrosol. A process for producing 4-(2-hydroxyethyl)-2-methoxyphenol is also disclosed.

  公开了一种从丁香酚制备羟基酪醇的方法。丁香酚可以转化为4-(2-羟乙基)-2-甲氧基苯酚，随后再转化为羟基酪醇。丁香酚也可以首先去甲基化，然后将反应产物进一步转化为羟基酪醇。还公开了一种生产4-(2-羟乙基)-2-甲氧基苯酚的方法。
• Sulfonium compounds, processes for preparing the compounds and
  申请人：Taiho Pharmaceutical Company Limited

  公开号：US04556737A1

  公开（公告）日：1985-12-03

  This invention provides novel sulfonium compounds, processes for the preparation of the sulfonium compounds, and pharmacological composition containing the sulfonium compound. The compounds of this invention are useful for treating allergy.

  这项发明提供了新型砜化合物，制备砜化合物的方法，以及含有砜化合物的药理组合物。这项发明的化合物对治疗过敏症非常有用。
• CYCLIC AMIDE DERIVATIVE
  申请人：Okano Akihiro

  公开号：US20130203739A1

  公开（公告）日：2013-08-08

  [Problem] To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogues and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases. [Means of solving the problem] A compound of Formula (1): (where n is 0 to 2; p is 0 to 4; h is 0 to 3; j is 0 to 3; k is 0 to 2; a ring B is an aryl group or a heteroaryl group; X is O, S, or —NR 7 —; J 1 is —CR 11a R 11b — or —NR 11c —; J 2 is —CR 12a R 12b — or —NR 12c —; and R 1 to R 12c are specific groups), a salt of the compound, or a solvate of the salt or the compound.

  为提供一种具有GPR40激活剂作用的新化合物、该化合物的盐、盐或化合物的溶剂合物，尤其是胰岛素分泌剂和预防和/或治疗糖尿病、肥胖或其他疾病的药剂，解决问题的方法是使用Formula (1)的化合物：(其中n为0至2；p为0至4；h为0至3；j为0至3；k为0至2；环B为芳香族或杂环芳基；X为O、S或-NR7-；J1为-CR11aR11b-或-NR11c-；J2为-CR12aR12b-或-NR12c-；R1到R12为特定基团)，该化合物的盐，或盐或化合物的溶剂合物。
• NOVEL 3-HYDROXYISOTHIAZOLE 1-OXIDE DERIVATIVE
  申请人：OHKOUCHI Munetaka

  公开号：US20120277150A1

  公开（公告）日：2012-11-01

  [Object] To provide a GPR40 activating agent containing, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the compound or the salt, or the like, particularly, an insulin secretagogue and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases. [Means of Solving the Problem] A compound of Formula (I): (where p is 0 to 4; j is 0 to 2; k is 0 to 1; a ring A is an aryl group, a heterocyclic group, a cycroalkyl group, a cycroalkenyl group, a spirocyclic group; a ring B is an aryl group, a heteroaryl group; X is 0 or —NR 7 —; and R 1 to R 7 and L are specific groups), a salt of the compound, or a solvate of the compound or the salt.

  提供一种包含GPR40激活剂的药剂，其活性成分为具有GPR40激动剂作用的新化合物、该化合物的盐、该化合物或盐的溶剂化合物等，特别是胰岛素促分泌剂和预防和/或治疗糖尿病、肥胖或其他疾病的药物。解决问题的方法是使用式(I)的化合物：（其中p为0至4；j为0至2；k为0至1；环A为芳基、杂环基、环烷基、环烯基、螺环基；环B为芳基、杂芳基；X为0或-NR7-；R1至R7和L为特定基团），该化合物的盐或该化合物或盐的溶剂化合物。