hispolon

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: hispolon
• 英文别名: 6-(3,4-dihydroxyphenyl)-4 hydroxyhexa-3,5-dien-2-one；6-(3,4-Dihydroxyphenyl)-4-hydroxy-3,5-hexadien-2-one；6-(3,4-dihydroxyphenyl)-4-hydroxyhexa-3,5-dien-2-one
• 化学式: C₁₂H₁₂O₄
• 分子量: 220.225
• InChiKey: QDVIEIMMEUCFMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  hispolon 、 水杨醛 在 哌啶 、 boron trioxide 、 硼酸三乙酯 作用下， 以 1,4-二氧六环 为溶剂， 以6%的产率得到(1E,6E)-7-(3,4-dihydroxyphenyl)-5-hydroxy-1-(2-hydroxyphenyl)hepta-1,4,6-trien-3-one
  参考文献：
  名称：

  Structure activity relationship study of curcumin analogues toward the amyloid-beta aggregation inhibitor

  摘要：

  Inhibition of the amyloid beta aggregation process could possibly prevent the onset of Alzheimer's disease. In this article, we report a structure-activity relationship study of curcumin analogues for anti amyloid beta aggregation activity. Compound 7, the ideal amyloid beta aggregation inhibitor in vitro among synthesized curcumin analogues, has not only potent anti amyloid beta aggregation effects, but also water solubility more than 160 times that of curcumin. In addition, new approaches to improve water solubility of curcumin-type compounds are proposed. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.10.076
• 作为产物：
  描述：

  乙酰丙酮 、 3,4-二羟基苯甲醛 在 哌啶 、 boron trioxide 、 硼酸三乙酯 作用下， 以 1,4-二氧六环 为溶剂， 以10%的产率得到1,7-bis(3,4-dihydroxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one
  参考文献：
  名称：

  Structure activity relationship study of curcumin analogues toward the amyloid-beta aggregation inhibitor

  摘要：

  Inhibition of the amyloid beta aggregation process could possibly prevent the onset of Alzheimer's disease. In this article, we report a structure-activity relationship study of curcumin analogues for anti amyloid beta aggregation activity. Compound 7, the ideal amyloid beta aggregation inhibitor in vitro among synthesized curcumin analogues, has not only potent anti amyloid beta aggregation effects, but also water solubility more than 160 times that of curcumin. In addition, new approaches to improve water solubility of curcumin-type compounds are proposed. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.10.076