4-nitrobenzoic acid | 29788-29-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-nitrobenzoic acid
• 英文别名: 4-(Dihydroxyamino)benzoic acid
• CAS: 29788-29-2
• 化学式: C₇H₇NO₄
• 分子量: 169.137
• InChiKey: QJTKOGOFSWJPKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  81
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-nitrobenzoic acid 、 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以61 mg的产率得到4-nitro-N-((2R,3S,4R,5R,6S,7R)-2,3,5,7-tetramethyl-1-oxaspiro[5.5]undecan-4-yl)benzamide
  参考文献：
  名称：

  用酮进行的Prins反应：Portentol骨架合成的合理化和应用

  摘要：

  我们报告与酮作为羰基伙伴的TMSI促进Prins环化反应，以制备多取代的手性螺四氢吡喃。在外消旋2-甲基环己酮的存在下，发生动态动力学拆分，得到一种立体异构体。观察到的对映体特异性已通过DFT计算得到了合理化。

  DOI：

  10.1021/ol202829u

文献信息

• PROCESS FOR PREPARING FLOWABLE AMORPHOUS POLY-ALPHA OLEFIN ADHESIVE PELLETS
  申请人：Henkel US IP LLC

  公开号：EP2892965A1

  公开（公告）日：2015-07-15
• EFFICIENT ASPIRIN PRODRUGS
  申请人：Gilmer John Francis

  公开号：US20110046182A1

  公开（公告）日：2011-02-24

  Aspirin is one of the most widely used drugs in the treatment of inflammation, pain and fever. It has more recently found application in the prevention of heart attacks and stroke and is being studied as a cancer chemopreventative agent. Despite its value aspirin continues to be underutilized because it causes gastric bleeding. The technology under development potentially removes this problem. It is designed to reduce contact between the drug and the intestinal lining. An isosorbide aspirinate prodrug compound is thus provided. The compound has the general structure as shown in general formula (I) wherein Y is a C 1 -C 8 alkyl ester, a C 1 -C 8 alkoxy ester, a C 3 -C 10 cycloalkyl ester, an arylester, a C 1 -C 8 alkylaryl ester or —C(O)OR ring , wherein R ring is a 5-membered aromatic or nonaromatic 5-member ring having at least one heteroatom substituted for a carbon of the ring system, which can be unsubstituted or substituted with at least one nitric oxide releasing group.
• [EN] PROCESS FOR PREPARING FLOWABLE AMORPHOUS POLY-ALPHA OLEFIN ADHESIVE PELLETS<br/>[FR] PROCÉDÉ POUR PRÉPARER DES GRANULES D'ADHÉSIF DE POLY-ALPHA-OLÉFINE AMORPHES FLUIDES
  申请人：HENKEL US IP LLC

  公开号：WO2013177382A1

  公开（公告）日：2013-11-28

  The present invention relates to a process for producing free-flowing, agglomeration resistant amorphous poly-alpha--olefin based adhesive pellets. The process includes (a) extruding the adhesive through an orifice of a die plate immersed in a cooling fluid; (b) cutting the adhesive into a plurality of pellets in the cooling fluid; (c) solidifying the pellets at a temperature range of about 25°C to about 4Q°C for at (east 30 minutes; and (6) separating the pellets from the recrystallization fluid and drying; the pellets. The pellets harden at least three folds faster than conventionally formed pellets.
• [EN] HIGH GLASS TRANSITION TEMPERATURE THERMOSET AND METHOD OF MAKING THE SAME<br/>[FR] THERMODURCISSABLE À TEMPÉRATURE DE TRANSITION VITREUSE ÉLEVÉE ET SON PROCÉDÉ DE PRÉPARATION
  申请人：BAKER HUGHES INC

  公开号：WO2014014590A1

  公开（公告）日：2014-01-23

  Process for preparing nanocomposite includes combining resin and silsesquioxane; introducing a curing agent to the resin and silsesquioxane to form a composition; and forming a reaction product of the composition to prepare the nanocomposite, wherein a total amount of silsesquioxane and curing agent in the composition is from 1 wt% to 70 wt%, based on a weight of the composition. Additionally, a process for preparing an article includes combining epoxy resin and silsesquioxane; introducing a curing agent to the epoxy resin and silsesquioxane to form a composition; and reacting the epoxy resin, silsesquioxane, and curing agent to form the nanocomposite, wherein a molar ratio of a number of moles of an epoxy functional group of the epoxy resin to the sum of the number of moles of the silsesquioxane and curing agent is from 1:1 to 100:1. Article includes the reaction product of the resin, silsesquioxane, and curing agent.