2,4-di-tert-butyl-benzoic acid | 14035-04-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-di-tert-butyl-benzoic acid
• 英文别名: 2,4-Di-tert-butyl-benzoesaeure；2,4-Ditert-butylbenzoic acid
• CAS: 14035-04-2
• 化学式: C₁₅H₂₂O₂
• 分子量: 234.338
• InChiKey: PINAENFSXQEGCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-氨基苯基苯甲酮 、 2,4-di-tert-butyl-benzoic acid 在 polymer-bound EDC 作用下， 生成 N-(3-Benzoyl-phenyl)-2,4-di-tert-butyl-benzamide
  参考文献：
  名称：

  Utility of Complementary Molecular Reactivity and Molecular Recognition (CMR/R) Technology and Polymer-Supported Reagents in the Solution-Phase Synthesis of Heterocyclic Carboxamides

  摘要：

  The use of our recently reported chemical library purification strategy in the development of a herbicidal lead, N-(3-benzoylphenyl)-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-carboxamide (3), is described. The approach applying fundamental properties of complementary molecular reactivity and molecular recognition (CMR/R) as the basis for a general purification strategy was utilized. Polymeric reagents were used in the synthesis to generate reactive species involved in product formation, and complementary molecular reactivity/molecular recognition polymer 8 (CMR/R polymer 8) was used in the solution-phase syntheses of building blocks, primary libraries, and lead refinement libraries. An extension of the CMR/R methodology was applied, utilizing a sequestration enabling reagent (SER), transforming a reactant into an electrophilic species sequestrable by CMR/R polymer 8. This library purification strategy enabled rapid lead generation and lead refinement to afford herbicide 27o. The CMR/R solid-phase purification technique enabled a simple, general, and powerful protocol, eliminating the usual tedious and time-consuming methods required for solution-phase product purification. The result was the synthesis of hundreds of compounds, prepared in a relatively short time, leading to a compound with a 4-fold improvement in herbicidal activity over the initial lead.

  DOI：

  10.1021/jo970571i
• 作为产物：
  描述：

  1,3-di-tert-butyl-4-methylbenzene 在 吡啶 、 氢氧化钾 、 potassium permanganate 作用下， 生成 2,4-di-tert-butyl-benzoic acid
  参考文献：
  名称：

  Baas,J.M.A.; Wepster,B.M., Recueil des Travaux Chimiques des Pays-Bas, 1967, vol. 86, p. 69 - 79

  摘要：

  DOI：

文献信息

• Polypropylene-based resin compositions
  申请人：TOSOH CORPORATION

  公开号：EP0507576A1

  公开（公告）日：1992-10-07

  A polypropylene-based resin composition containing 0.001 to 10.0 parts by weight of benzoic acid with or without substituent(s) on its benzene ring and/or an acid anhydride of benzoic acid, with or without substituents on its benzene rings, to 100 parts by weight of a polypropylene-based resin is disclosed. The resin can generate mouldings with improved rigidity or transparency.

  本发明公开了一种聚丙烯基树脂组合物，以 100 份聚丙烯基树脂的重量计，含有 0.001 至 10.0 份苯甲酸（无论其苯环上是否有取代基）和/或苯甲酸酸酐（无论其苯环上是否有取代基）。该树脂可制成具有更高硬度或透明度的模制品。
• Colloidal suspensions of nanoscale particles
  申请人：Koninklijke Philips Electronics N.V.

  公开号：EP1923449A1

  公开（公告）日：2008-05-21

  The present invention relates to a suspension of colloidal nanoscale particles based on lanthanide phosphates and/or lanthanide vanadates, and in particular to a stabilised suspension of colloidal nanoscale particles comprising carboxylic acid ligands. The colloidal nanoscale particles of the stabilised suspension have a low average particle size and a narrow particle size distribution. The present invention furthermore relates to a method of producing the suspensions of colloidal nanoscale particles, and particularly to a method where the lanthanide cation is bound to a chelating agent before it is converted to lanthanide phosphate or lanthanide vanadate. The invention also relates to various uses of the suspension.

  本发明涉及一种基于镧系磷酸盐和/或镧系钒酸盐的胶体纳米级颗粒悬浮液，尤其涉及一种包含羧酸配体的胶体纳米级颗粒稳定悬浮液。稳定悬浮液中的胶体纳米级颗粒具有较低的平均粒径和较窄的粒径分布。本发明还涉及一种生产胶体纳米级颗粒悬浮液的方法，特别是涉及一种在镧系阳离子转化为磷酸镧系元素或钒酸镧系元素之前将其与螯合剂结合的方法。本发明还涉及悬浮液的各种用途。
• Beets et al., Recueil des Travaux Chimiques des Pays-Bas, 1959, vol. 78, p. 570,582
  作者：Beets et al.

  DOI：——

  日期：——
• Glycopeptide Antibiotic Monomer Derivatives
  申请人：Arimoto Hirokazu

  公开号：US20080097078A1

  公开（公告）日：2008-04-24

  Novel glycopeptide antibiotic derivatives. These derivatives are represented by the formula (aglycon part of glycopeptide antibiotic derivative)-(Sac-NH)—R A [wherein (aglycon part of glycopeptide antibiotic derivative) is the part formed by removing the sugar part from a known glycopeptide antibiotic derivative; (Sac-NH) part is an amino sugar part or a sugar chain part containing an amino sugar; and R A represents, e.g., the formula —X 1 —Ar 1 —X 2 —Y—X 3 —Ar 2 (wherein X 1 , X 2 , and X 3 each represents 1) a single bond or 2) a heteroatom or heteroatom-containing group selected from the group consisting of —N═, ═N—, —NR 1 —, —O—, etc.; Y represents —NR 2 CO— or —CONR 2 — (wherein R 2 represents hydrogen or lower alkyl), etc.)]. These derivatives have antibacterial activity against vancomycin-resistant bacteria.
• LOW MODULUS NEGATIVE TONE, AQUEOUS DEVELOPABLE PHOTORESIST
  申请人：Designer Molecules, Inc.

  公开号：US20150344627A1

  公开（公告）日：2015-12-03

  Hydrophobic, low modulus, photoimagable, functionalized polyimides have been discovered that can be developed using aqueous solutions. In particular, compositions containing the functionalized polyimides of the current invention can be used in the photolithography step for the passivation layer on a silicon wafer to reduce stress in thin wafers, or as a low modulus hydrophobic solder mask. These materials can serve as protective layers in other applications in which a thin, flexible, and hydrophobic polymer is required.