N,N'-Dibutylbenzene-1,3-dicarbaldimine | 85068-02-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-Dibutylbenzene-1,3-dicarbaldimine
• 英文别名: 1,3-bis((N-butyl)iminomethyl)phenylene；N-butyl-1-[3-(butyliminomethyl)phenyl]methanimine
• CAS: 85068-02-6
• 化学式: C₁₆H₂₄N₂
• 分子量: 244.38
• InChiKey: RKJJAJXCVQVMQN-UHFFFAOYSA-N

物化性质

• 沸点：
  371.9±25.0 °C(Predicted)
• 密度：
  0.90±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-Dibutylbenzene-1,3-dicarbaldimine 在 sodium tetrahydroborate 作用下， 生成 N,N'-Dibutyl-m-phenylen-dimethanamin
  参考文献：
  名称：

  低聚胺的抗聚集和抗凝特性，第 3 版：间亚苯基双氨基烷烃

  摘要：

  合成了17个标题化合物，其中16个在40~6 μmol/L浓度下抑制胶原诱导的血小板聚集50%。血浆的凝固性 - 表现为凝血活酶和部分凝血活酶时间的延长 - 在 4·10-4 和 1·10-4 mol / L 之间的浓度下降低到正常值的 25%。

  DOI：

  10.1002/ardp.19873200308
• 作为产物：
  描述：

  间苯二甲醛 、 正丁胺 生成 N,N'-Dibutylbenzene-1,3-dicarbaldimine
  参考文献：
  名称：

  低聚胺的抗聚集和抗凝特性，第 3 版：间亚苯基双氨基烷烃

  摘要：

  合成了17个标题化合物，其中16个在40~6 μmol/L浓度下抑制胶原诱导的血小板聚集50%。血浆的凝固性 - 表现为凝血活酶和部分凝血活酶时间的延长 - 在 4·10-4 和 1·10-4 mol / L 之间的浓度下降低到正常值的 25%。

  DOI：

  10.1002/ardp.19873200308

文献信息

• METHOD OF PRODUCING IMINES
  申请人：Sithambaram Shanthakumar

  公开号：US20070027344A1

  公开（公告）日：2007-02-01

  A method for forming an imine comprises reacting a first reactant comprising a hydroxyl functionality, a carbonyl functionality, or both a hydroxyl functionality and a carbonyl functionality with a second reactant having an amine functionality in the presence of ordered porous manganese-based octahedral molecular sieves and an oxygen containing gas at a temperature and for a time sufficient for the imine to be produced.

  形成亚胺的方法包括在有序多孔锰基八面体分子筛和含氧气体的存在下，将包含羟基功能、酮基功能或羟基功能和酮基功能的第一反应物与具有胺功能的第二反应物反应，反应温度和时间足以产生亚胺。
• A Direct Route to Platinum NCN-Pincer Complexes Derived from 1,3-Bis(imino)benzenes and an Investigation into Their Activity as Catalysts for Carbon−Carbon Bond Formation
  作者：John S. Fossey、Christopher J. Richards

  DOI：10.1021/om020566r

  日期：2002.11.1

  to platinum, as established by an X-ray crystal structure of ((2,6-bis(N-tert-butyl)imino)phenyl)aquoplatinum(II) trifluoromethanesulfonate. Use of 4−5 mol % of ((2,6-bis(N-cyclohexyl)imino)phenyl)aquoplatinum(II) trifluoromethanesulfonate accelerated the rate of the Michael reaction between ethyl α-cyanoacetate and methyl vinyl ketone and the Diels−Alder reaction between acrylonitrile and cyclopentadiene

  1，3-双（亚氨基）苯[1,3-C 6 H 4（CH NR）2 ]，由1,3-间苯二甲醛与伯胺的缩合反应制得（R = t Bu，Cy，Bu，Bn，Ph ）与K 2 PtCl 4在冰醋酸中加热回流48小时，得到（（2,6-双（N -R-取代的亚氨基）亚氨基）苯基）氯化铂（II）络合物（收率15-52％ ）。报道了R ＝t Bu和R ＝ Ph配合物的X射线晶体结构。发现副产物为1，3-间苯二甲醛和N-乙酰基胺。用AgBF 4（R = t Bu）或AgOTf（R = t卜，CY）提供了含有配位到铂水相应的阳离子络合物，通过X射线晶体结构确定（（2,6-双（ñ -叔丁基）亚氨基）苯基）aquoplatinum（II）三氟甲磺酸酯。使用4-5 mol％的（（2,6-双（N-环己基）亚氨基）苯基）铂（II）三氟甲磺酸盐可加快α-氰基乙酸乙酯与甲基乙烯基酮和Diels-Alder之间的Michael反应速率丙烯腈与环戊二烯之间的反应。
• Preparation of benzenetetracarboxylic acids by the cobalt-catalyzed carbonylation of Schiff bases from benzenedicarbaldehydes and subsequent oxidation
  作者：Tsunesuke Kajimoto、Jiro Tsuji

  DOI：10.1021/jo00158a020

  日期：1983.5
• Synthesis and reactions of cyclopalladated compounds derived from N,N′-dialkylbenzene-1,3-dicarbaldimines [alkyl = ethyl (H₂L¹), butyl or octyl] and N,N′-dibenzylbenzene-1,3-dicarbaldimine. Crystal structure of [Pd₂L¹(py)₄][ClO₄]₂(py = pyridine)
  作者：Sukla Chakladar、Parimal Paul、K. Venkatsubramanian、Kamalaksha Nag

  DOI：10.1039/dt9910002669

  日期：——

  The reactions of N,N'-dialkylbenzene-1,3-dicarbaldimines (alkyl = Et, H2L1; Bu, H2L2 or C8H17, H2L3) and N,N'-dibenzylbenzene-1,3-dicarbaldimine (H2L4) with Pd(O2CMe)2 have been studied. In all cases tetra-mu-acetato cyclopalladated compounds, [Pd4L2(O2CMe)4], were obtained in which metallation had occurred at the 4,6 positions of the benzene ring. The mu-chloro analgoues, [Pd4L2Cl4], can be obtained either by reaction of the Schiff bases with Li2[PdCl4] or by metathesis of the acetato complexes. Bridge-splitting reactions of [Pd4L2Cl4] with pyridine(py), 4-methylpyridine, pyrazole, 3,5-dimethylpyrazole, amines, and a number of monoprotic bidentate chelating ligands, viz. acetylacetone, dibenzoylmethane and its monothio analogue, ethylacetoacetate, salicylaldehyde, N-methylsalicylideneimine and sodium N,N-dipropyldithiocarbamate have also been investigated. The products have been characterized by H-1 and C-13 NMR spectroscopy. The X-ray crystal structure of [Pd2L1(py)4][ClO4]2 has been determined which crystallizes in the triclinic space group P1BAR with a = 10.889(1), b = 16.981(2), c = 10.227(1) angstrom, alpha = 92.99(1), beta = 93.14(1), gamma = 73.65(1)-degrees and Z = 2; refinement led to R = 0.059 and R' = 0.062 using 3620 unique reflections with I > 3-sigma(I).