2-(5-(2-hydroxyethyl)furan-2-yl)acetic acid | 1018901-08-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-(5-(2-hydroxyethyl)furan-2-yl)acetic acid
• 英文别名: 5-(2-Hydroxyethyl)-2-furanacetic acid；2-[5-(2-hydroxyethyl)furan-2-yl]acetic acid
• CAS: 1018901-08-0
• 化学式: C₈H₁₀O₄
• 分子量: 170.165
• InChiKey: QWLLYAHKDUIWRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(5-(2-hydroxyethyl)furan-2-yl)acetic acid 在 4-二甲氨基吡啶 、 2,6-二氯苯甲酰氯 作用下， 以 二氯甲烷 为溶剂， 以33.4%的产率得到4,13,19,20-tetraoxatricyclo[14.2.1.1(7,10)]icosa-1(18),7,9,16-tetraene-3,12-dione
  参考文献：
  名称：

  Macrocyclisation of 2-(5-(2-hydroxyethyl)furan-2-yl)acetic acid model compounds of nonactic acid

  摘要：

  The macrocyclisation of hydroxyethylfuranyl acetic acid and of dehydrogenated model compounds of nonactic acid was investigated to develop a facile synthesis of nonactin analogues. By applying the Yamagushi macrocyclisation to our omega-hydroxyacids, we were able to isolate a mixture of di-, tri-, tetra- and pentameric macrocycles.

  DOI：

  10.1007/s00706-008-0031-4
• 作为产物：
  描述：

  ethyl 2-(5-(2-hydroxyethyl)furan-2-yl)acetate 在 potassium hydroxide 、 盐酸 、 水 作用下， 以 乙醇 为溶剂， 以95%的产率得到2-(5-(2-hydroxyethyl)furan-2-yl)acetic acid
  参考文献：
  名称：

  Macrocyclisation of 2-(5-(2-hydroxyethyl)furan-2-yl)acetic acid model compounds of nonactic acid

  摘要：

  The macrocyclisation of hydroxyethylfuranyl acetic acid and of dehydrogenated model compounds of nonactic acid was investigated to develop a facile synthesis of nonactin analogues. By applying the Yamagushi macrocyclisation to our omega-hydroxyacids, we were able to isolate a mixture of di-, tri-, tetra- and pentameric macrocycles.

  DOI：

  10.1007/s00706-008-0031-4

文献信息

• Macrocyclisation of 2-(5-(2-hydroxyethyl)furan-2-yl)acetic acid model compounds of nonactic acid
  作者：Carine Eng、Jean-Mary Simone、Akane Hartenbach、François Loiseau、Reinhard Neier

  DOI：10.1007/s00706-008-0031-4

  日期：2009.3

  The macrocyclisation of hydroxyethylfuranyl acetic acid and of dehydrogenated model compounds of nonactic acid was investigated to develop a facile synthesis of nonactin analogues. By applying the Yamagushi macrocyclisation to our omega-hydroxyacids, we were able to isolate a mixture of di-, tri-, tetra- and pentameric macrocycles.