2-(1,4,8,11-Tetrazacyclotetradec-1-ylmethyl)benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(1,4,8,11-Tetrazacyclotetradec-1-ylmethyl)benzoic acid
• 化学式: C₁₈H₃₀N₄O₂
• 分子量: 334.5
• InChiKey: SBDRAAFDUHSEPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  76.6
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• MMP-TARGETED THERAPEUTIC AND/OR DIAGNOSTIC NANOCARRIERS
  申请人：Mallinckrodt Inc.

  公开号：US20130183236A1

  公开（公告）日：2013-07-18

  The present invention provides targeted delivery compositions and methods of using the compositions for treating and diagnosing a disease state in a subject.

  本发明提供了针对性递送组合物以及使用这些组合物治疗和诊断受试者疾病状态的方法。
• Remote Assembly of Targeted Nanoparticles Using H-Phosphonate -ENE/-YNE Hydrophosphonylation Reactions
  申请人：Mallinckrodt LLC

  公开号：US20160060280A1

  公开（公告）日：2016-03-03

  The present invention provides phosphonate compounds and methods of preparing the phosphonate compounds so as to allow, for example, increased capability to modify nanoparticles for targeted drug delivery applications.

  本发明提供了膦酸盐化合物及其制备方法，以便例如增强修饰纳米颗粒以用于靶向药物传递应用的能力。
• Neutralizing antibodies to the αvβ8 integrin complex for immunotherapy
  申请人：The Regents of the University of California

  公开号：US10954304B2

  公开（公告）日：2021-03-23

  Provided is an antibody that specifically binds human αvββ and blocks binding of TGFp peptide to αvβ8, wherein the antibody binds to the specificity determining loop (SDL) of human β8. In some embodiments, the antibody further binds to one, two, or all three of the human av-head domain, the al helix of human β8, or the al helix of human β8. In some embodiments, the antibody is humanized or chimeric. In some embodiments, the antibody is linked to a detectable label. Also provided is a method of enhancing an immune response in a human individual, comprising administering a sufficient amount of the antibody to the individual, thereby enhancing an immune response. Also provided are pharmaceutical compositions comprising the anti-αvββ antibodies or antigen-binding molecules thereof.

  本研究提供了一种抗体，它能特异性地结合人 αvββ 并阻断 TGFp 肽与αvβ8 的结合，其中该抗体与人β8 的特异性决定环（SDL）结合。在某些实施方案中，抗体进一步与人类 av 头结构域、人类 β8 的 al 螺旋或人类 β8 的 al 螺旋中的一个、两个或全部三个结合。在某些实施方案中，抗体是人源化的或嵌合的。在某些实施方案中，抗体与可检测标签相连。还提供了一种增强人体免疫应答的方法，包括向人体施用足量的抗体，从而增强免疫应答。还提供了包含抗αvββ抗体或其抗原结合分子的药物组合物。
• DRUG DELIVERY SYSTEM FOR PHARMACEUTICALS AND RADIATION
  申请人：Wang Zhuang

  公开号：US20110027172A1

  公开（公告）日：2011-02-03

  The present invention provides a drug delivery system for delivery of an agent and a radiopharmaceutical agent. The drug delivery system may specifically target an organ, tissue, cells, extracellular matrix, or intracellular compartment. Typically, the drug delivery system is a particle. Pharmaceutical compositions comprising the inventive particles are also provided. The present invention provides methods of preparing and using the inventive particles and pharmaceutical compositions. The inventive particles are useful in treating and diagnosing a variety of diseases including cancer. The inventive particles are also useful in tracking particles in vivo.
• Aptamer Conjugates for Targeting of Therapeutic and/or Diagnostic Nanocarriers
  申请人：Trawick Bobby N.

  公开号：US20120082616A1

  公开（公告）日：2012-04-05

  The present invention provides targeted delivery compositions and their methods of use in treating and diagnosing a disease state in a subject.